U.S. Department of Agriculture: Agricultural Research Service, Lincoln, Nebraska

 

Document Type

Article

Date of this Version

4-3-2006

Comments

Published in PNAS April 11, 2006 Vol. 103 no. 15 6049-6054. Includes supplemental supporting information.

Abstract

TheArabidopsis homolog of trithorax, ATX1, regulates numerous functions inArabidopsis beyond the homeotic genes. Here, we identified genome-wide targets of ATX1 and showed that ATX1 is a receptor for a lipid messenger, phosphatidylinositol 5-phosphate, PI5P. PI5P negatively affects ATX1 activity, suggesting a regulatory pathway connecting lipid-signaling with nuclear functions. We propose a model to illustrate how plants may respond to stimuli (external or internal) that elevate cellular PI5P levels by altering expression of ATX1-controlled genes.

Includes supplemental supporting information.

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