One-Pot Catalyst-Free Synthesis of β- and γ-Hydroxy Sulfides Using Diaryliodonium Salts and Microwave Irradiation

Authors

• Buchi Reddy Vaddula, U.S. EPA
• Rajender S. Varma, U.S. EPAFollow
• John Leazer, U.S. EPAFollow

Document Type

Article

Date of this Version

2012

Citation

Published in Eur. J. Org. Chem. (2012) 1-19. DOI:10.1002/ejoc.201201313

Abstract

A simple and rapid one-pot protocol is described for the preparation of α- and β-hydroxy sulfides. The direct solventfree microwave irradiation of diaryliodonium salts, potassium thiocyanate, and ethylene glycol/β-propylene glycol without any catalyst or base affords the final compounds in good yields (65–95%) in around 10–25 min.