Tsuji–Trost N-Allylation with Allylic Acetates by Using a Cellulose–Palladium Catalyst

Authors

• Buchi Reddy Vaddula, U.S. EPA
• Amit Saha, U.S. EPA
• Rajender S. Varma, U.S. EPAFollow
• John Leazer, U.S. EPAFollow

Document Type

Article

Date of this Version

2012

Citation

Published in Eur. J. Org. Chem. 2012, 6707–6709. DOI:10.1002/ejoc.201201241

Abstract

Allylic amines were synthesized by a simple procedure using a biodegradable and easily recyclable heterogeneous cellulose– Pd catalyst through N-allylation of primary and secondary amines. The scope of this protocol includes aliphatic and benzylamines with substituted and unsubstituted allyl acetates and culminates in high yield syntheses. The highlights of the protocol include a ligand-free reaction, simple workup, and catalyst recyclability.