One-Pot Catalyst-Free Synthesis of β- and γ-Hydroxy Sulfides Using Diaryliodonium Salts and Microwave Irradiation

Authors

Buchi Reddy Vaddula, U.S. EPA
Rajender S. Varma, U.S. EPAFollow
John Leazer, U.S. EPAFollow

Date of this Version

2012

Citation

Published in Eur. J. Org. Chem. (2012) 1-19. DOI:10.1002/ejoc.201201313

Abstract

A simple and rapid one-pot protocol is described for the preparation of α- and β-hydroxy sulfides. The direct solventfree microwave irradiation of diaryliodonium salts, potassium thiocyanate, and ethylene glycol/β-propylene glycol without any catalyst or base affords the final compounds in good yields (65–95%) in around 10–25 min.