N R Jayagopala (Jay) Reddy, MVSc, PhD
Associate Professor, ISU/UNL Cooperative Veterinary Medicine Education Program

Research Description: Our long-term interest is the cellular and molecular mechanisms underlying the development of human autoimmune diseases. Most healthy humans have a propensity to develop autoimmune diseases, as evidenced by the presence of autoreactive T cells or autoantibodies in their naïve periphery. T cells are educated in the thymus, where high-affinity TCR-bearing cells that interact with self-antigens are deleted by negative selection while T cells with low-affinity TCR to self-antigens are selected positively and exported to the periphery. In spite of the high frequency of self-reactive T cells in the naïve peripheral repertoires, autoimmune responses do not ensue spontaneously. How this tolerance is maintained is a fundamental question. We focus our investigations on the role of reactive oxygen species in the maintenance of T cell tolerance and autoimmunity.

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2016

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A Urinary Metabolic Signature for Multiple Sclerosis and Neuromyelitis Optica, Teklab Gebregiworgis, Helle H. Nielsen, Chandirasegara Massilamany, Arunakumar Gangaplara, Jay Reddy, Zsolt Illes, and Robert Powers

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Whole genomic sequence analysis of Bacillus infantis: defining the genetic blueprint of strain NRRL B-14911, an emerging cardiopathogenic microbe, Chandirasegara Massilamany, Akram Mohammed, John Dustin Loy, Tanya Purvis, Bharathi Krishnan, Rakesh H. Basavalingappa, Christy M. Kelley, Chittibabu Guda, Raúl G. Barletta, Etsuko Moriyama, Timothy P.L. Smith, and Jay Reddy

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Noninvasive Assessment of Cardiac Abnormalities in Experimental Autoimmune Myocarditis by Magnetic Resonance Microscopy Imaging in the Mouse, Chandirasegaran Massilamany, Vahid Khalilzad-Sharghi, Arunakumar Gangaplara, David Steffen, Shadi F. Othman, and Jay Reddy

2015

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Versatility of using major histocompatibility complex class II dextramers for derivation and characterization of antigen-specific, autoreactive T cell hybridomas, Bharathi Krishnan, Chandirasegaran Massilamany, Rakesh H. Basavalingappa, Rajkumar A. Rajasekaran, Charles Kuszynski, Barbara Switzer, Daniel A. Peterson, and Jay Reddy

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Major Histocompatibility Complex Class II Dextramers: New Tools for the Detection of antigen-Specific, CD4 T Cells in Basic and Clinical Research, Chandirasegara Massilamany, Bharathi Krishnan, and Jay Reddy

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Mutations in the 5’ NTR and the Non-Structural Protein 3A of the Coxsackievirus B3 Selectively Attenuate Myocarditogenicity, Chandirasegaran Massilamany, Arunakumar Gangaplara, Rakesh H. Basavalingappa, Rajkumar A. Rajasekaran, Hiep Vu, Jean-Jack Riethoven, David Steffen, Asit K. Pattnaik, and Jay Reddy

2014

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Direct Staining with Major Histocompatibility Complex Class II Dextramers Permits Detection of Antigen- Specific, Autoreactive CD4 T Cells In Situ, Chandirasegaran Massilamany, Arunakumar Gangaplara, Ting Jia, Christian Elowsky, Guobin Kang, Jean-Jack Riethoven, Qingsheng Li, You Zhou, and Jay Reddy

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SJL Mice Infected with Acanthamoeba castellanii Develop Central Nervous System Autoimmunity through the Generation of Cross-Reactive T Cells for Myelin Antigens, Jay Reddy, Chandirasegaran Massilamany, Francine Marciano-Cabral, Bruno da Rocha-Azevedo, Melissa Jamerson, Arunakumar Gangaplara, David Steffen, Rana Zabad, Zsolt Illes, and Raymond Sobel

2013

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Mimicry epitope from Ehrlichia canis for interphotoreceptor retinoid-binding protein 201–216 prevents autoimmune uveoretinitis by acting as altered peptide ligand, Arunakumar Gangaplara, Chandirasegaran Massilamany, David Steffen, and Jay Reddy

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Relevance of Molecular Mimicry in the Mediation of Infectious Myocarditis, Chandirasegaran Massilamany, Sally A. Huber, Madeleine W. Cunningham, and Jay Reddy

2012

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Coxsackievirus B3 Infection Leads to the Generation of Cardiac Myosin Heavy Chain-α-Reactive CD4 T Cells in A/J Mice, Arunakumar Gangaplara, Chandirasegaran Massilamany, Deborah M. Brown, Gustavo A. Delhon, Asit K. Pattnaik, Nora Chapman, Noel Rose, David J. Steffen, and Jay Reddy

2011

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Detection of cardiac myosin heavy chain-α-specific CD4 cells by using MHC class II/IAk tetramers in A/J mice, Chandirasegara Massilamany, Arunakumar Gangaplara, Nora M. Chapman, Noel Rose, and Jay Reddy

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Identification of a Second Mimicry Epitope from Acanthamoeba castellanii that Induces CNS Autoimmunity by Generating Cross-reactive T Cells for MBP 89–101 in SJL Mice, Chandirasegaran Massilamany, Oluwatoyin A. Asojo, Arunakumar Gangaplara, David J. Steffen, and Jay Reddy

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Identification of a Second Mimicry Epitope from Acanthamoeba castellanii that Induces CNS Autoimmunity by Generating Cross-Reactive T Cells for MBP 89–101 in SJL Mice, Chandirasegaran Massilamany, Oluwatoyin A. Asojo, Arunakumar Gangaplara, David J. Steffen, and Jay Reddy

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TCA Cycle Inactivation in Staphylococcus aureus Alters Nitric Oxide Production in RAW 264.7 Cells, Chandirasegaran Massilamany, Arunakumar Gangaplara, Donald J. Gardner, James M. Musser, David J. Steffen, Greg A. Somerville, and Jay Reddy

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Detection of autoreactive CD4 T cells using major histocompatibility complex class II dextramers, Chandirasegaran Massilamany, Bijaya Upadhyaya, Arunakumar Gangaplara, Charles Kuszynski, and Jay Reddy

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Gender differences in CNS autoimmunity induced by mimicry epitope for PLP 139–151 in SJL mice, Chandirasegara Massilamany, Sivasubramani Thulasingam, David Steffen, and Jay Reddy

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Detection of Autoreactive CD4 T Cells Using Major Histocompatibility Complex Class II Dextramers, Chandirasegaran Massilimany, Bijaya Upadhyaya, Arunakumar Gangaplara, Charles Kuszynski, and Jay Reddy

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miR-27b*, an Oxidative Stress-Responsive microRNA Modulates Nuclear Factor-kB Pathway in RAW 264.7 Cells, Sivasubramani Thulasingam, Candirasegaran Massilamany, Arunakumar Gangaplara, Hongjiu Dai, Shahlo Yarbaeva, Sakthivel Subramaniam, Jean-Jack Riethoven, James Eudy, Marjorie F. Lou, and Jay Reddy

2010

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An Epitope from Acanthamoeba castellanii That Cross-React with Proteolipid Protein 139-151-Reactive T Cells Induces Autoimmune Encephalomyelitis in SJL Mice, Chandirasegaran Massilamany, David Steffan, and Jay Reddy

2009

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Synergistic Inhibition of Bovine Leukemia Virus Replication In Vitro by Ribavirin and alpha-Interferon [abstract only], Jeffrey Isaacson, Charles Wood, and Jay Reddy

2008

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Distinct Functions of Autoreactive Memory and Effector CD4+ T Cells in Experimental Autoimmune Encephalomyelitis, Wassim Elyaman, Pia Kivisäkk, Jay Reddy, Tanuja Chitnis, Khadir Raddassi, Jaime Imitola, Elizabeth Bradshaw, Vijay K. Kuchroo, Hideo Yagita, Mohamed H. Sayegh, and Samia J. Khoury

2007

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Modulation of CD4 Co-Receptor Limits Spontaneous Autoimmunity When High-Affinity Transgenic TCR Specific for Self-Antigen Is Expressed on a Genetically Resistant Background, Zsolt Illés, Hanspeter Waldner, Jay Reddy, Ana C. Anderson, Raymond A. Sobel, and Vijay K. Kuchroo

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Su.32. Myelin-specific Regulatory T Cells Accumulate in the Central Nervous System, but Fail to Suppress Pathogenic Effector T Cells at the Peak of Autoimmune Inflammation [abstract only], Thomas Korn, Mohamed Oukka, Jay Reddy, Estelle Betelli, Amit Awasthi, Raymond Sobel, Kai Wucherpfennig, and Vijay K. Kuchroo

2006

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Monoclonal Antibodies to Distinct Regions of Human Myelin Proteolipid Protein Simultaneously Recognize Central Nervous System Myelin and Neurons of Many Vertebrate Species, Edward A. Greenfield, Jay Reddy, Andrew Lees, Charissa A. Dyer, Omanand Koul, Khuong Nguyen, Shannon Bell, Nasim Kassam, Julian Hinojoza, Mary Jane Eaton, Marjorie B. Lees, Vijay K. Kuchroo, and Raymond A. Sobel

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OR.76. Myelin Specific Regulatory T-Cells Expand from Naturally Occurring Regulatory T-Cells and Accumulate in the CNS during EAE [abstract only], Thomas Korn, Jay Reddy, Wenda Gao, Terry Strom, Mohamed Oukka, and Vijay K. Kuchroo

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OR.107. TIM-1 Plays a Crucial Role in the Expansion of Autopathogneic T-Cells and Regulation of Autoimmunity [abstract only], Sheng Xioa, Nader Najafian, Jay Reddy, Monica Albin, Chen Zhu, Ana Anderson, Zheng Zhang, Cristina Gutierrez, Raymond Sobel, Dale Umetsu, Hideo Yagita, Hisaya Akiba, Mohamed Sayegh, Rosemarie DeKruyff, and Vijay K. Kuchroo

2005

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Cutting Edge: CD4+CD25+ Regulatory T Cells Contribute to Gender Differences in Susceptibility to Experimental Autoimmune Encephalomyelitis, Jay Reddy, Hanspeter Waldner, Xingmin Zhang, Zsolt Illes, Kai W. Wucherpfennig, Raymond A. Sobel, and Vijay K. Kuchroo

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Peptide 15-mers of Defined Sequence that Substitute for Random Amino Acid Copolymers in Amelioration of Experimental Autoimmune Encephalomyelitis, Joel N.H. Stern, Zsolt Illés, Jay Reddy, Derin B. Keskin, Masha Fridkis-Hareli, Vijay K. Kuchroo, and Jack L. Strominger

2004

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Modified Amino Acid Copolymers Suppress Myelin Basic Protein 85–99-Induced Encephalomyelitis in Humanized Mice through Different Effects on T Cells, Zsolt Illés, Joel N.H. Stern, Jay Reddy, Hanspeter Waldner, Marcin P. Mycko, Celia F. Brosnan, Stephan Ellmerich, Daniel M. Altmann, Laura Santambrogio, Jack L. Strominger, and Vijay K. Kuchroo

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Myelin Proteolipid Protein-Specific CD4+ CD25+ Regulatory Cells Mediate Genetic Resistance to Experimental Autoimmune Encephalomyelitis, Jay Reddy, Zsolt Illés, Xingmin Zhang, Jeffrey Encinas, Jason Pyrdol, Lindsay Nicholson, Raymond A. Sobel, Kai W. Wucherpfennig, Vijay K. Kuchroo, and James P. Allison

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Amelioration of Proteolipid Protein 139–151-Induced Encephalomyelitis in SJL Mice by Modified Amino Acid Copolymers and Their Mechanisms, Joel N.H. Stern, Zsolt Illés, Jay Reddy, Derin B. Keskin, Eric Sheu, Masha Fridkis-Hareli, Hiroyuki Nishimura, Celia F. Brosnan, Laura Santambrogio, Vijay K. Kuchroo, and Jack L. Strominger

1996

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Cytokines in Pigs Bred Selectively for High and Low Immune Response [abstract only], Jay Reddy, Bruce N. Wilkie, Bonnie A. Mallard, and Soren Rosendal