Veterinary and Biomedical Sciences, Department of

 

Document Type

Article

Date of this Version

5-6-2014

Citation

United States Patent Kwong et al. Patent No.: US 8,715,686 B2

Abstract

Isolated immunogens including a HIV-1 gp120 polypeptide or immunogenic fragment thereof stabilized in a CD4 bound confirmation by crosslinked cysteines, and methods of their use are disclosed. The immunogens are useful, for example, for generating an immune response to HIV-1 gp120 in a Subject.

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