Veterinary and Biomedical Sciences, School of
School of Veterinary and Biomedical Sciences: Faculty Publications
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Document Type
Article
Date of this Version
5-6-2014
Citation
United States Patent Kwong et al. Patent No.: US 8,715,686 B2
Abstract
Isolated immunogens including a HIV-1 gp120 polypeptide or immunogenic fragment thereof stabilized in a CD4 bound confirmation by crosslinked cysteines, and methods of their use are disclosed. The immunogens are useful, for example, for generating an immune response to HIV-1 gp120 in a Subject.
Included in
Biochemistry, Biophysics, and Structural Biology Commons, Cell and Developmental Biology Commons, Immunology and Infectious Disease Commons, Medical Sciences Commons, Veterinary Microbiology and Immunobiology Commons, Veterinary Pathology and Pathobiology Commons