Next-Generation Sequencing in Equine Genomics

Authors

Jessica L. Petersen, University of Nebraska-LincolnFollow
Stephen J. Coleman, Colorado State UniversityFollow

Date of this Version

8-2020

Citation

Veterinary Clinics of North America: Equine Practice 36:2 (August 2020), pp. 195–209.

doi: 10.1016/j.cveq.2020.03.002

Comments

Copyright © 2020 Elsevier, Inc. Used by permission.

Abstract

• Next-generation sequencing of both DNA and RNA represents a second revolution in equine genetics following publication of the equine genome sequence.

• Technological advancements have resulted in a wide selection of next-generation sequencing platforms capable of completing small targeted experiments or resequencing complete genomes.

• DNA and RNA sequencing have applications in clinical and research environments.

• Standards for the validation and sharing of next-generation sequencing data are critical for the widespread application of the technology and applications discussed herein.

• As researchers and clinicians develop a better understanding of how genetic variation and phenotypic variation are linked, next-generation sequencing could help pave the way to personalized and precision management of horses.