Date of this Version
Veterinary Clinics of North America: Equine Practice 36:2 (August 2020), pp. 195–209.
- Next-generation sequencing of both DNA and RNA represents a second revolution in equine genetics following publication of the equine genome sequence.
- Technological advancements have resulted in a wide selection of next-generation sequencing platforms capable of completing small targeted experiments or resequencing complete genomes.
- DNA and RNA sequencing have applications in clinical and research environments.
- Standards for the validation and sharing of next-generation sequencing data are critical for the widespread application of the technology and applications discussed herein.
- As researchers and clinicians develop a better understanding of how genetic variation and phenotypic variation are linked, next-generation sequencing could help pave the way to personalized and precision management of horses.