Large-scale Clinical Trial to Evaluate an Experimental Escherichia coli Vaccine

Authors

• Robert E. Peterson, University of Nebraska-Lincoln
• David R. Smith, University of Nebraska-LincolnFollow
• Rodney A. Moxley, University of Nebraska-LincolnFollow
• Terry J. Klopfenstein, University of Nebraska-LincolnFollow
• Susan Hinkley, University of Nebraska-Lincoln
• Galen E. Erickson, University of Nebraska-LincolnFollow

Date of this Version

January 2006

Comments

Published in 2006 Nebraska Beef Cattle Report. Copyright © 2005 The Board of Regents of the University of Nebraska.

Abstract

A clinical trial was conducted within 19 Nebraska feedlots to evaluate effects of an E. coli vaccine on the probability to detect E. coli O157:H7 on ROPES or for cattle to be colonized by E. coli O157:H7 at the terminal rectum. Vaccinated pens of cattle were less likely to test ROPE-positive than nonvaccinated pens of cattle and a lower probability for E. coli O157:H7 colonization among vaccinated cattle compared with nonvaccinated cattle was observed. The vaccine was effective at reducing E. coli O157:H7 in the feedlot pen environment and colonization at the terminal rectum of cattle.