Conjugated Linoleic Acid Metabolism and Body Fat Loss in Mice

Authors

Kim Hargrave, University of Nebraska-Lincoln
Brett Meyer, University of Nebraska-Lincoln
Jess L. Miner, University of Nebraska-LincolnFollow

Date of this Version

January 2004

Comments

Published in 2004 Nebraska Beef Cattle Report. Copyright © 2003 The Board of Regents of the University of Nebraska.

Abstract

Mice were fed conjugated linoleic acid (CLA) with or without fish oil or aspirin, which deplete tissue arachidonic acid and block arachidonic acid metabolism, respectively. Mice fed fish oil did not lose body fat when supplemented with CLA but mice fed soy oil did. Aspirin did not alter CLA-induced body fat loss. CLA may be metabolized to an isomer of arachidonic acid to induce a loss of body fat. However, this body fat loss is apparently not mediated via alteration of prostaglandin synthesis. Understanding the regulation of body fat by CLA may offer insight into the mechanisms of body fat regulation in cattle.