Follicular Vascular Endothelial Growth Factor A Expression Before and After the LH Surge

Authors

Renee M. McFee, University of Nebraska–LincolnFollow
Robin A. Artac, University of Nebraska–Lincoln
Adam F. Summers, University of Nebraska–LincolnFollow
William E. Pohlmeier, University of Nebraska–Lincoln
Vanessa M. Brauer, University of Nebraska–Lincoln
Scott G. Kurz, University of Nebraska–Lincoln
Robert A. Cushman, U.S. Meat Animal Research CenterFollow
Jennifer R. Wood, University of Nebraska–LincolnFollow
Andrea S. Cupp, University of Nebraska–LincolnFollow

Date of this Version

2014

Citation

2014 Nebraska Beef Cattle Report, UNL Extension MP99, pp. 14-16.

Comments

Copyright © 2014 University of Nebraska.

Abstract

Granulosa cell expression of VEGFAisoforms in dominant bovine follicles was evaluated. Collection of granulosa cells via follicle aspiration revealed altered expression of the proangiogenic VEGFA_164 isoform but not the antiangiogenic VEGFA_164B isoform prior to and after the LH surge. Expression of VEGFA_164 declines as both the LH surge and ovulation approaches. In addition, VEGFA_164 and VEGFA_164B expression prior to the LH surge was positively correlated with FSHR and CYP19A1 expression, suggesting that VEGFA expression may be regulated by FSH. These data indicate differential expression of VEGFA isoforms may be an important feature of bovine dominant follicle development.