Vascular Endothelial Growth Factor Inhibitory Isoform Is Regulated Prior to Ovulation

Authors

Robin A. Ten Broeck, University of Nebraska-Lincoln
Debra T. Clopton, University of Nebraska-LincolnFollow
Jeremy L. Martin, University of Nebraska-Lincoln
Karl V. Moline, University of Nebraska-LincolnFollow
Jeffrey W. Bergman, University of Nebraska-LincolnFollow
Andrea S. Cupp, University of Nebraska-LincolnFollow

Date of this Version

January 2007

Comments

Published in 2007 Nebraska Beef Cattle Report. Copyright © 2006 The Board of Regents of the University of Nebraska.

Abstract

VEGF normally acts to stimulate vascular development (angiogenesis) and is necessary for ovulation of the dominant follicle. The inhibitory isoform blocks the actions of VEGF angiogenic isoforms; therefore, the objectives of the experiments were to identify the bovine inhibitory isoform, VEGF164b and to determine its expression prior to and after the LH surge. VEGF164b mRNA was upregulated prior to but did not change after the LH surge. Therefore, VEGF164b may be necessary for preparation of the dominant follicle prior to ovulation.