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Document Type
Article
Date of this Version
2014
Citation
THE JOURNAL OF BIOLOGICAL CHEMISTRY VOL. 289, NO. 40, pp. 27794–27806, October 3, 2014
Abstract
Background: Proline is an important amino acid for stress resistance in different organisms.
Results: Depletion of proline biosynthesis disrupts redox homeostasis and increases sensitivity to endoplasmic reticulum (ER) stress in yeast.
Conclusion: Proline biosynthesis is critical for maintaining the intracellular redox environment and the UPR during ER stress.
Significance: Proline metabolism is shown to have an important role in ER stress tolerance that was previously unknown.
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Comments
© 2014 by The American Society for Biochemistry and Molecular Biology, Inc.