Cytosolic Fe-S Cluster Protein Maturation and Iron Regulation Are Independent of the Mitochondrial Erv1/Mia40 Import System

Authors

Hatice K. Ozer, University of South Carolina, Columbia
Adrienne C. Dlouhy, University of South Carolina, Columbia
Jeremy D. Thornton, Norwich Research Park, Norwich
Jingjing Hu, University of South Carolina, Columbia
Yilin Liu, University of Nebraska, Lincoln
Joseph J. Barycki, University of Nebraska - LincolnFollow
Janneke Balk, Norwich Research Park, Norwich
Caryn E. Outten, University of South Carolina, Columbia

Document Type

Article

Date of this Version

2015

Citation

THE JOURNAL OF BIOLOGICAL CHEMISTRY VOL. 290, NO. 46, pp. 27829–27840 , November 13, 2015

Comments

© 2015 by The American Society for Biochemistry and Molecular Biology, Inc.

Abstract

Background: The mitochondrial sulfhydryl oxidase Erv1 is implicated in cytosolic iron-sulfur protein maturation and iron regulation.

Results: An erv1 yeast strain used in previous iron metabolism studies is glutathione-deficient, and erv1/mia40 mutants with sufficient glutathione do not exhibit iron-related defects.

Conclusion: Iron homeostasis is independent of Erv1/Mia40 function. Significance: The unexplained role of Erv1 in yeast iron metabolism is resolved.