TGD1, -2, and -3 Proteins Involved in Lipid Trafficking Form ATP-binding Cassette (ABC) Transporter with Multiple Substrate-binding Proteins

Authors

Rebecca Roston, University of Nebraska- LincolnFollow
Jinpeng Gao, Michigan State University
Monika W. Murcha, University of Western Australia
James Whelan, University of Western Australia
Christoph Benning, Michigan State University

Document Type

Article

Date of this Version

2012

Citation

The Journal of Biological Chemistry VOL. 287, NO. 25, pp. 21406–21415, June 15, 2012

Comments

© 2012 by The American Society for Biochemistry and Molecular Biology, Inc.

Abstract

Background: ATP-binding cassette transporters exist in all life forms and usually require only one substrate-binding domain.

Results: The TRIGALACTOSYLDIACYLGLYCEROL (TGD) complex contains 8–12 substrate-binding proteins.

Conclusion: Multiple substrate-binding proteins may be needed by the TGD complex to enhance its putative lipid transport activity.

Significance: Knowing the subunit stoichiometry of the TGD complex furthers understanding of lipid transfer between chloroplast membranes.