TGD1, -2, and -3 Proteins Involved in Lipid Trafficking Form ATP-binding Cassette (ABC) Transporter with Multiple Substrate-binding Proteins

Authors

• Rebecca Roston, University of Nebraska- LincolnFollow
• Jinpeng Gao, Michigan State University
• Monika W. Murcha, University of Western Australia
• James Whelan, University of Western Australia
• Christoph Benning, Michigan State University

Document Type

Article

Date of this Version

2012

Citation

The Journal of Biological Chemistry VOL. 287, NO. 25, pp. 21406–21415, June 15, 2012

Comments

© 2012 by The American Society for Biochemistry and Molecular Biology, Inc.

Abstract

Background: ATP-binding cassette transporters exist in all life forms and usually require only one substrate-binding domain.

Results: The TRIGALACTOSYLDIACYLGLYCEROL (TGD) complex contains 8–12 substrate-binding proteins.

Conclusion: Multiple substrate-binding proteins may be needed by the TGD complex to enhance its putative lipid transport activity.

Significance: Knowing the subunit stoichiometry of the TGD complex furthers understanding of lipid transfer between chloroplast membranes.