Mitochondrial Protein Quality Control: The Mechanisms Guarding Mitochondrial Health

Authors

Iryna Bohovych, University of Nebraska- LincolnFollow
Sherine S.L. Chan, Medical University of South CarolinaFollow
Oleh Khalimonchuk, University of Nebraska-LincolnFollow

Document Type

Article

Date of this Version

2015

Citation

ANTIOXIDANTS & REDOX SIGNALING Volume 22, Number 12, 2015
DOI: 10.1089/ars.2014.6199

Comments

Copyright 2015 Mary Ann Liebert, Inc.

Link goes to free-access file on NIH PubMed Central site.

Abstract

Significance: Mitochondria are complex dynamic organelles pivotal for cellular physiology and human health. Failure to maintain mitochondrial health leads to numerous maladies that include late-onset neurodegenerative diseases and cardiovascular disorders. Furthermore, a decline in mitochondrial health is prevalent with aging. A set of evolutionary conserved mechanisms known as mitochondrial quality control (MQC) is involved in recognition and correction of the mitochondrial proteome. Recent Advances: Here, we review current knowledge and latest developments in MQC. We particularly focus on the proteolytic aspect of MQC and its impact on health and aging. Critical Issues: While our knowledge about MQC is steadily growing, critical gaps remain in the mechanistic understanding of how MQC modules sense damage and preserve mitochondrial welfare, particularly in higher organisms. Future Directions: Delineating how coordinated action of the MQC modules orchestrates physiological responses on both organellar and cellular levels will further elucidate the current picture of MQC’s role and function in health, cellular stress, and degenerative diseases.