Pet191 Is a Cytochrome c Oxidase Assembly Factor in Saccharomyces cerevisiae

Authors

Oleh Khalimonchuk, University of Nebraska-LincolnFollow
Kevin Rigby, University of Utah Health Sciences Center
Megan Bestwick, University of Utah Health Sciences Center
Fabien Pierrel, University of Utah Health Sciences Center
Paul A. Cobine, University of Utah Health Sciences Center
Dennis R. Winge, University of Utah Health Sciences Center

Document Type

Article

Date of this Version

2008

Citation

EUKARYOTIC CELL, Aug. 2008, p. 1427–1431, Vol. 7, No. 8

Comments

Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Abstract

The twin-Cx₉C motif protein Pet191 is essential for cytochrome c oxidase maturation. The motif Cys residues are functionally important and appear to be present in disulfide linkages within a large oligomeric complex associated with the mitochondrial inner membrane. The import of Pet191 differs from that of other twin-Cx₉C motif class of proteins in being independent of the Mia40 pathway.