Pet191 Is a Cytochrome c Oxidase Assembly Factor in Saccharomyces cerevisiae

Authors

• Oleh Khalimonchuk, University of Nebraska-LincolnFollow
• Kevin Rigby, University of Utah Health Sciences Center
• Megan Bestwick, University of Utah Health Sciences Center
• Fabien Pierrel, University of Utah Health Sciences Center
• Paul A. Cobine, University of Utah Health Sciences Center
• Dennis R. Winge, University of Utah Health Sciences Center

Document Type

Article

Date of this Version

2008

Citation

EUKARYOTIC CELL, Aug. 2008, p. 1427–1431, Vol. 7, No. 8

Comments

Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Abstract

The twin-Cx₉C motif protein Pet191 is essential for cytochrome c oxidase maturation. The motif Cys residues are functionally important and appear to be present in disulfide linkages within a large oligomeric complex associated with the mitochondrial inner membrane. The import of Pet191 differs from that of other twin-Cx₉C motif class of proteins in being independent of the Mia40 pathway.