Ligand Binding and Signaling of HARE/Stabilin-2

Authors

Edward N. Harris, University of Nebraska - LincolnFollow
Fatima Cabral, University of Nebraska - Lincoln

Date of this Version

2019

Citation

Biomolecules 2019, 9, 273

Comments

© 2019 by the authors.

Open access

doi:10.3390/biom9070273

Abstract

The Stabilin receptors are a two-member family in the type H class of scavenger receptors. These dynamic receptors bind and internalize multiple ligands from the cell surface for the purpose of clearing extracellular material including some synthetic drugs and for sensing the external environment of the cell. Stabilin-1 was the first receptor to be cloned, though the biological activity of Hyaluronic Acid Receptor for Endocytosis (HARE)/Stabilin-2 was observed about 10 years prior to the cloning of Stabilin-1. Stabilin-1 has a more diverse expression profile among the tissues than HARE/Stabilin-2. This review will focus on HARE/Stabilin-2 and its interactions with hyaluronan, heparin, and phosphorothioate antisense oligonucleotides and what is known about how this receptor participates in signaling upon ligand binding.