Chemical and Biomolecular Engineering, Department of

 

Date of this Version

2008

Document Type

Article

Citation

Provisional application No. 60/904,681, filed on Mar. 2, 2007.

Comments

Used by permission.

Abstract

Micro-topography of a surface influences cell adhesion and proliferation. To improve adhesion, polyelectrolyte multilayers (PEMs) are built on patterned support layers to increase surface wettability, thereby improving attachment and spreading of the cells. Physical parameters, such as pattern size and pitch, in part, regulate cell adhesion and proliferation. Varying the surface topography provides a method to influence cell attachment and proliferation for tissue engineering applications.

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