Synergism between Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) and Salmonella choleraesuis

Authors

Robert Wills, University of Nebraska-Lincoln
Paula Fedorka-Cray, University of Nebraska-Lincoln
K.-J. Yoon, University of Nebraska-LincolnFollow
Jeffrey Gray, University of Nebraska-Lincoln
Tom Stabel, University of Nebraska-Lincoln
J. J. Zimmerman, University of Nebraska-Lincoln

Date of this Version

1997

Comments

Published in 1997 Nebraska Swine Report, edited by Duane Reese; published and copyright © 1997 Animal Science Department, University of Nebraska – Lincoln.

Abstract

This study was conducted to investigate the effects of exposure to porcine reproductive and respiratory syndrome virus, Salmonella choleraesuis and stress on young swine. Five week- old segregated early weaned pigs were randomly assigned to one of eight treatments consisting of all possible combinations of three factors: S. choleraesuis (SC) on day zero, porcine reproductive and respiratory syndrome virus (PRRSV) on day three, and dexamethasone (DEX) on days three to seven. DEX was used as a proxy for stress. Treatment differences were seen in performance parameters, levels and duration of SC shedding, level and distribution of SC in tissues, clinical disease, and mortality. The results of this study provided evidence to support field observations that clinical outbreaks of PRRS are the result of interactions among concurrent infections and stressors.