Disparate Metabolic Responses in Mice Fed a High-Fat Diet Supplemented with Maize-Derived Non-Digestible Feruloylated Oligo- and Polysaccharides Are Linked to Changes in the Gut Microbiota

Authors

Junyi Yang, Frontage Laboratories, Exton, PA
Laure B. Bindels, Université catholique de Louvain, BrusselsFollow
Rafael R. Segura Munoz, University of Nebraska-LincolnFollow
Inés Martínez, University of AlbertaFollow
Jens Walter, University of AlbertaFollow
Amanda Ramer-Tait, University of Nebraska-LincolnFollow
Devin J. Rose, University of Nebraska–LincolnFollow

Date of this Version

1-5-2016

Citation

Yang J, Bindels LB, Segura Munoz RR, Martínez I, Walter J, Ramer-Tait AE, et al. (2016) Disparate Metabolic Responses in Mice Fed a High- Fat Diet Supplemented with Maize-Derived Non- Digestible Feruloylated Oligo- and Polysaccharides Are Linked to Changes in the Gut Microbiota. PLoS ONE 11(1): e0146144. doi:10.1371/journal. pone.0146144

Comments

Copyright: © 2016 Yang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License

Abstract

Studies have suggested links between colonic fermentation of dietary fibers and improved metabolic health. The objectives of this study were to determine if non-digestible feruloylated oligo- and polysaccharides (FOPS), a maize-derived dietary fiber, could counteract the deleterious effects of high-fat (HF) feeding in mice and explore if metabolic benefits were linked to the gut microbiota. C57BL/6J mice (n = 8/group) were fed a low-fat (LF; 10 kcal% fat), HF (62 kcal% fat), or HF diet supplemented with FOPS (5%, w/w). Pronounced differences in FOPS responsiveness were observed: four mice experienced cecal enlargement and enhanced short chain fatty acid production, indicating increased cecal fermentation (F-FOPS). Only these mice displayed improvements in glucose metabolism compared with HF-fed mice. Blooms in the gut microbial genera Blautia and Akkermansia were observed in three of the F-FOPS mice; these shifts were associated with reductions in body and adipose tissue weights compared with the HF-fed control mice. No improvements in metabolic markers or weights were detected in the four mice whose gut microbiota did not respond to FOPS. These findings demonstrate that FOPS-induced improvements in weight gain and metabolic health in mice depended on the ability of an individual’s microbiota to ferment FOPS.