Food Science and Technology Department
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Department of Food Science and Technology: Faculty Publications
ORCID IDs
N. Banjara http://orcid.org/0000-0001-7293-0440
H. Hallen-Adams http://orcid.org/0000-0002-1929-725X
Document Type
Article
Date of this Version
2017
Citation
Published in Mycoses 2017; 1–9. DOI: 10.1111/myc.12603
Abstract
Small bowel transplantation (SBT) can be a life-saving medical procedure. However, these recipients experience high risk of bloodstream infections caused by Candida. This research aims to characterize the SBT recipient gut microbiota over time following transplantation and investigate the epidemiology of candidemia in seven pediatric patients. Candida species from the recipients’ ileum and bloodstream were identified by internal transcribed spacer sequence and distinguished to strain by multilocus sequence typing and randomly amplified polymorphic DNA. Antifungal susceptibility of bloodstream isolates was determined against nine antifungals. Twenty-two ileostomy samples harbored at least one Candida species. Fungemia were caused by Candida parapsilosis, Candida albicans, Candida glabrata, Candida orthopsilosis and Candida pelliculosa. All but three bloodstream isolates showed susceptibility to all the antifungals tested. One C. glabrata isolate showed multidrug resistance to itraconazole, amphotericin B and posaconazole and intermediate resistance to caspofungin. Results are congruent with both endogenous (C. albicans, C. glabrata) and exogenous (C. parapsilosis) infections; results also suggest two patients were infected by the same strain of C. parapsilosis. Continuing to work towards a better understanding of sources of infection—particularly the exogenous sources—would lead to targeted prevention strategies.
Includes supplementary materials.
Included in
Bacterial Infections and Mycoses Commons, Food Science Commons, Nutritional and Metabolic Diseases Commons, Surgery Commons
Comments
Copyright © 2017 Blackwell Verlag GmbH. Used by permission.