Food Science and Technology Department
Date of this Version
6-24-2011
Citation
2011 Segata et al.
Abstract
This study describes and validates a new method for metagenomic biomarker discovery by way of class comparison, tests of biological consistency and effect size estimation. This addresses the challenge of finding organisms, genes, or pathways that consistently explain the differences between two or more microbial communities, which is a central problem to the study of metagenomics. We extensively validate our method on several microbiomes and a convenient online interface for the method is provided at http://huttenhower.sph. harvard.edu/lefse/.
Comments
Segata et al. Genome Biology 2011, 12:R60 http://genomebiology.com/2011/11/6/R60 Page 1 of 18