Food Science and Technology Department



Dominique S. Michaud, Brown University & Imperial College LondonFollow
Jacques Izard, University of Nebraska–LincolnFollow
Zachary Rubin, Brown University
Ingegerd Johansson, Umeå University & Samfundet Folkhälsan
Elisabete Weiderpass, Samfundet Folkhälsan & University of Tromsø & Cancer Registry of Norway & Karolinska Institutet
Anne Tjønneland, Danish Cancer Society
Anja Olsen, Danish Cancer Society
Kim Overvad, Aarhus University
Marie Christine Boutron-Ruault, Centre for Research in Epidemiology and Population Health & Paris South University
Françoise Clavel-Chapelon, Centre for Research in Epidemiology and Population Health & Paris South University
Laure Dossus, Centre for Research in Epidemiology and Population Health & Paris South University
Rudolf Kaaks, German Cancer Research Center (DKFZ)
Verena A. Katzke, German Cancer Research Center (DKFZ)
Heiner Boeing, German Institute of Human Nutrition Potsdam-Rehbruecke
Jana Foerster, German Institute of Human Nutrition Potsdam-Rehbruecke
Antonia Trichopoulou, University of Athens Medical School & Hellenic Health Foundation
Androniki Naska, University of Athens Medical School
Giana Ziara, Hellenic Health Foundation
Paolo Vineis, Imperial College London & Center for Cancer Prevention (CPO-Piemonte) and Human Genetic Foundation (HuGeF)
Sara Grioni, Fondazione IRCCS Istituto Nazionale dei Tumori
Domenico Palli, ISPO- Cancer Research and Prevention Institute
Rosario Tumino, Cancer Registry and Histopathology Unit, “Civile - M.P.Arezzo” Hospital
Amalia Mattiello, Federico II University
Petra HM Peeters, University Medical Center Utrecht
Peter D. Siersema, University Medical Centre Utrecht (UMCU)
Aurelio Barricarte, Public Health Institute of Navarra & CIBER Epidemiología y Salud Pública (CIBERESP)
José-María Huerta, CIBER Epidemiología y Salud Pública (CIBERESP) & Murcia Regional Health Authority
Esther Molina-Montes, CIBER Epidemiología y Salud Pública (CIBERESP) & Andalusian School of Public Health
Miren Dorronsoro, Basque Regional Health Department
J. Ramón Quirós, Health and Health Care Services Council
Eric J. Duell, Cancer Epidemiology Research Programme
Bodil Ohlsson, Skåne University Hospital
Bengt Jeppsson, Lund University and Skåne University Hosptial
Anders Johansson, Umeå University
Pernilla Lif, Umeå University
Kay-Tee Khaw, University of Cambridge
Nick Wareham, MRC Epidemiology Unit
Ruth C. Travis, University of Oxford
Tim J. Key, University of Oxford
Heinz Freisling, International Agency for Research on Cancer (IARC-WHO)
Talita Duarte-Salles, International Agency for Research on Cancer (IARC-WHO)
Magdalena Stepien, International Agency for Research on Cancer (IARC-WHO)
Elio Riboli, Imperial College London
H. Bas Bueno-de- Mesquita, University Medical Centre Utrecht (UMCU) & National Institute for Public Health and the Environment (RIVM)

Date of this Version



Cancer Causes Control. 2013 November ; 24(11): . doi:10.1007/s10552-013-0265-2


Michaud et al. Page 1-13


Background—Increasing evidence suggests that oral microbiota play a pivotal role in chronic diseases, in addition to the well-established role in periodontal disease. Moreover, recent studies suggest that oral bacteria may also be involved in carcinogenesis; periodontal disease has been linked several cancers. In this study, we examined whether lifestyle factors have an impact on antibody levels to oral bacteria.

Methods—Data on demographic characteristics, lifestyle factors, and medical conditions were obtained at the time of blood sample collection. For the current analysis, we measured antibody levels to 25 oral bacteria in 395 cancer-free individuals using an immunoblot array. Combined total immunglobin G (IgG) levels were obtained by summing concentrations for all oral bacteria measured.

Results—IgG antibody levels were substantially lower among current and former smokers (1697 and 1677 ng/mL, respectively) than never smokers (1960 ng/mL; p-trend = 0.01), but did not vary by other factors, including BMI, diabetes, physical activity, or by dietary factors, after adjusting for age, sex, education, country and smoking status. The highest levels of total IgG were found among individuals with low education (2419 ng/mL).

Conclusions—Our findings on smoking are consistent with previous studies and support the notion that smokers have a compromised humoral immune response. Moreover, other major factors known to be associated with inflammatory markers, including obesity, were not associated with antibody levels to a large number of oral bacteria.

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