Threshold Dose for Shrimp: A Risk Characterization Based on Objective Reactions in Clinical Studies

Authors

Julie A. Nordlee, University of Nebraska-LincolnFollow
Benjamin C. Remington, University of Nebraska-Lincoln
Barbara K. Ballmer-Weber, University Hospital of ZurichFollow
Samuel B. Lehrer, Tulane University Medical Center
Joe L. Baumert, University of Nebraska-LincolnFollow
Steve L. Taylor, University of Nebraska-LincolnFollow

Document Type

Article

Date of this Version

2-2013

Citation

Journal of Allergy and Clinical Immunology (February 2013) 131(2, Supplement): AB88 (no. 318)

doi: 10.1016/j.jaci.2012.12.980

Comments

Copyright © 2013, American Academy of Allergy, Asthma and Immunology. Published by Elsevier. Used by permission

Abstract

A DBPCFC [double-blind, placebo-controlled food challenge] of shrimp-allergic adults was conducted to obtain individual threshold doses. Results of this study and published research were combined and a population threshold for shrimp was determined from dose-distribution modeling. The shrimp-allergic population seems to have a higher threshold compared to other populations for other food allergens. Additional shrimp challenges should be done to confirm these initial results.