Peanut Allergen Reaction Thresholds during Controlled Food Challenges in 2 Canadian Randomized Studies (Canada-ARM1 and PISCES)

Authors

Derek K. Chu, McMaster University and St. Joe's HamiltonFollow
Joseph L. Baumert, University of Nebraska-LincolnFollow
Steve L. Taylor, University of Nebraska-LincolnFollow
Julie A. Nordlee, University of Nebraska-LincolnFollow
Tina Nham, McMaster University
Jonathan Bramson, McMaster UniversityFollow
Sébastien La Vieille, Health CanadaFollow
Michael A. Abbott, Health CanadaFollow
Paul Spill, McMaster University
Andrea Marrin, McMaster University
Manel Jordana, McMaster UniversityFollow
Susan Waserman, McMaster University and St. Joe's HamiltonFollow

Document Type

Article

Date of this Version

6-2021

Citation

Journal of Allergy and Clinical Immunology: In Practice (June 2021) 9(6): 2,524–2,526 .e2

doi: 10.1016/j.jaip.2021.02.009

Comments

Copyright © 2021, American Academy of Allergy, Asthma and Immunology. Published by Elsevier. Used by permission

Abstract

In 2 randomized studies addressing peanut allergy (Canada-Food Allergy Risk Management 1 [NCT01812798] and Peanut Immunotherapy Starting in Canada, Evaluation and DiScovery [NCT0 1601522]), we quantified peanut allergen thresholds to food challenge using Bayesian stacked model averaging to inform policy and clinical practice. About 50% of patients tolerated more than 70 mg (~ ¼ peanut).