Peanut Allergen Reaction Thresholds during Controlled Food Challenges in 2 Canadian Randomized Studies (Canada-ARM1 and PISCES)

Authors

• Derek K. Chu, McMaster University and St. Joe's HamiltonFollow
• Joseph L. Baumert, University of Nebraska-LincolnFollow
• Steve L. Taylor, University of Nebraska-LincolnFollow
• Julie A. Nordlee, University of Nebraska-LincolnFollow
• Tina Nham, McMaster University
• Jonathan Bramson, McMaster UniversityFollow
• Sébastien La Vieille, Health CanadaFollow
• Michael A. Abbott, Health CanadaFollow
• Paul Spill, McMaster University
• Andrea Marrin, McMaster University
• Manel Jordana, McMaster UniversityFollow
• Susan Waserman, McMaster University and St. Joe's HamiltonFollow

Document Type

Article

Date of this Version

6-2021

Citation

Journal of Allergy and Clinical Immunology: In Practice (June 2021) 9(6): 2,524–2,526 .e2

doi: 10.1016/j.jaip.2021.02.009

Comments

Copyright © 2021, American Academy of Allergy, Asthma and Immunology. Published by Elsevier. Used by permission

Abstract

In 2 randomized studies addressing peanut allergy (Canada-Food Allergy Risk Management 1 [NCT01812798] and Peanut Immunotherapy Starting in Canada, Evaluation and DiScovery [NCT0 1601522]), we quantified peanut allergen thresholds to food challenge using Bayesian stacked model averaging to inform policy and clinical practice. About 50% of patients tolerated more than 70 mg (~ ¼ peanut).