Modeling and Analyzing Homogeneous Tumor Growth under Virotherapy

Authors

Chayu Yang, University of Nebraska-LincolnFollow
Jin Wang, University of Tennessee at Chattanooga

Date of this Version

1-10-2023

Citation

Yang, C.;Wang, J. Modeling and Analyzing Homogeneous Tumor Growth under Virotherapy. Mathematics 2023, 11, 360. https:// doi.org/10.3390/math11020360

Comments

Open access.

Abstract

We present a mathematical model based on ordinary differential equations to investigate the spatially homogeneous state of tumor growth under virotherapy. The model emphasizes the interaction among the tumor cells, the oncolytic viruses, and the host immune system that generates both innate and adaptive immune responses. We conduct a rigorous equilibrium analysis and derive threshold conditions that determine the growth or decay of the tumor under various scenarios. Numerical simulation results verify our analytical predictions and provide additional insight into the tumor growth dynamics.