idmTPreg: Regression Model for Progressive Illness Death Data

Authors

• Leyla Azarang, BCAM-Basque Center for Applied Mathematics
• Manuel Oviedo de la Fuente, Universidade de Santiago de Compostela

Date of this Version

12-2018

Document Type

Article

Citation

The R Journal (December 2018) 10(2); Editor: John Verzani

Comments

Copyright 2018, The R Foundation. Open access material. License: CC BY 4.0 International

Abstract

The progressive illness-death model is frequently used in medical applications. For example, the model may be used to describe the disease process in cancer studies. We have developed a new R package called idmTPreg to estimate regression coefficients in datasets that can be described by the progressive illness-death model. The motivation for the development of the package is a recent contribution that enables the estimation of possibly time-varying covariate effects on the transition probabilities for a progressive illness-death data. The main feature of the package is that it befits both non-Markov and Markov progressive illness-death data. The package implements the introduced estimators obtained using a direct binomial regression approach. Also, variance estimates and confidence bands are implemented in the package. This article presents guidelines for the use of the package.