Clonal distribution and associated characteristics of Escherichia coli clinical and surveillance isolates from a military medical center

Authors

Amee R. Manges, University of British ColumbiaFollow
Katrin Mende, Uniformed Services University of the Health SciencesFollow
Clinton K. Murray, San Antonio Military Medical CenterFollow
Brian D. Johnson, University of MinnesotaFollow
Evgeni V. Sokurenko, University of WashingtonFollow
Veronika Tchesnokova, University of WashingtonFollow
James R. Johnson, University of MinnesotaFollow

Date of this Version

2017

Citation

Diagnostic Microbiology and Infectious Disease 87 (2017), pp. 382–385.

Comments

U.S. government work.

Abstract

Antimicrobial-resistant Escherichia coli are a concern for military health services. We studied 100 extended-spectrum beta-lactamase (ESBL)-producing and non-producing E. coli clinical and surveillance isolates from military personnel and civilians at Brooke Army Medical Center (2007–2011). Major E. coli lineages, most prominently ST10 (24%), ST131 (16%), and ST648 (8%), were distributed much as reported for other North American populations. ST131, represented mainly by its resistance-associated ST131-H30 clonal subset,was uniquely associated with a clinical origin, regardless of ESBL status. Thus, clonal background predicted resistance phenotype and clinical versus surveillance origin, and these findings could assist military clinicians and epidemiologists.