Clonal distribution and associated characteristics of Escherichia coli clinical and surveillance isolates from a military medical center

Authors

• Amee R. Manges, University of British ColumbiaFollow
• Katrin Mende, Uniformed Services University of the Health SciencesFollow
• Clinton K. Murray, San Antonio Military Medical CenterFollow
• Brian D. Johnson, University of MinnesotaFollow
• Evgeni V. Sokurenko, University of WashingtonFollow
• Veronika Tchesnokova, University of WashingtonFollow
• James R. Johnson, University of MinnesotaFollow

Date of this Version

2017

Citation

Diagnostic Microbiology and Infectious Disease 87 (2017), pp. 382–385.

Comments

U.S. government work.

Abstract

Antimicrobial-resistant Escherichia coli are a concern for military health services. We studied 100 extended-spectrum beta-lactamase (ESBL)-producing and non-producing E. coli clinical and surveillance isolates from military personnel and civilians at Brooke Army Medical Center (2007–2011). Major E. coli lineages, most prominently ST10 (24%), ST131 (16%), and ST648 (8%), were distributed much as reported for other North American populations. ST131, represented mainly by its resistance-associated ST131-H30 clonal subset,was uniquely associated with a clinical origin, regardless of ESBL status. Thus, clonal background predicted resistance phenotype and clinical versus surveillance origin, and these findings could assist military clinicians and epidemiologists.