Veterinary and Biomedical Sciences, Department of

 

Document Type

Article

Date of this Version

5-13-2008

Comments

United States Patent No.: US 7,371,571 B2
Barletta et al.
Date of Patent: May 13, 2008

Abstract

Recombinant mycobacterial strains which overproduce essential biosynthetic enzymes of pathogenic mycobateria are provided. These strains overproduce enzymes involved in the synthesis and incorporation of D-alanine into mycobacterial peptidoglycan, the backbone of the mycobacterial cell wall. These overproducing strains may be used as reference strains in in vitro screening methods to identify antimycobacterial agents.

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