Veterinary and Biomedical Sciences, Department of
Date of this Version
5-13-2008
Abstract
Recombinant mycobacterial strains which overproduce essential biosynthetic enzymes of pathogenic mycobateria are provided. These strains overproduce enzymes involved in the synthesis and incorporation of D-alanine into mycobacterial peptidoglycan, the backbone of the mycobacterial cell wall. These overproducing strains may be used as reference strains in in vitro screening methods to identify antimycobacterial agents.
Comments
United States Patent No.: US 7,371,571 B2
Barletta et al.
Date of Patent: May 13, 2008