Pathogenicity of an Enterotoxigenic Escherichia coli Hemolysin (hlyA) Mutant in Gnotobiotic Piglets

Authors

Rodney A. Moxley, University of Nebraska - LincolnFollow
Emil M. Berberov, University of Nebraska - Lincoln
David H. Francis, South Dakota State UniversityFollow
Jun Xing, University of Nebraska - Lincoln
Mahtab Moayeri, University of Wisconsin, Madison, Wisconsin
Rodney A. Welsch, University of Wisconsin, Madison, Wisconsin
Diane R. Baker, South Dakota State University, Brookings, South Dakota
Raul G. Barletta, University of Nebraska - LincolnFollow

Document Type

Article

Date of this Version

10-1-1998

Comments

Published in INFECTION AND IMMUNITY, Oct. 1998, p. 5031–5035 Vol. 66, No. 10. Copyright © 1998, American Society for Microbiology. Used by permission.

Abstract

Pigs infected with hemolytic F4⁺ strains of enterotoxigenic Escherichia coli often develop septicemia secondary to intestinal infection. We tested the hypothesis that inactivation of hemolysin would reduce the ability of F4⁺ enterotoxigenic E. coli to cause septicemia in swine following oral inoculation. Inactivation of the hemolysin structural gene (hlyA) did not decrease the incidence of septicemia in the gnotobiotic piglet model.