Pathogenicity of an Enterotoxigenic Escherichia coli Hemolysin (hlyA) Mutant in Gnotobiotic Piglets

Authors

• Rodney A. Moxley, University of Nebraska - LincolnFollow
• Emil M. Berberov, University of Nebraska - Lincoln
• David H. Francis, South Dakota State UniversityFollow
• Jun Xing, University of Nebraska - Lincoln
• Mahtab Moayeri, University of Wisconsin, Madison, Wisconsin
• Rodney A. Welsch, University of Wisconsin, Madison, Wisconsin
• Diane R. Baker, South Dakota State University, Brookings, South Dakota
• Raul G. Barletta, University of Nebraska - LincolnFollow

Document Type

Article

Date of this Version

10-1-1998

Comments

Published in INFECTION AND IMMUNITY, Oct. 1998, p. 5031–5035 Vol. 66, No. 10. Copyright © 1998, American Society for Microbiology. Used by permission.

Abstract

Pigs infected with hemolytic F4⁺ strains of enterotoxigenic Escherichia coli often develop septicemia secondary to intestinal infection. We tested the hypothesis that inactivation of hemolysin would reduce the ability of F4⁺ enterotoxigenic E. coli to cause septicemia in swine following oral inoculation. Inactivation of the hemolysin structural gene (hlyA) did not decrease the incidence of septicemia in the gnotobiotic piglet model.