Veterinary and Biomedical Sciences, Department of

 

Document Type

Article

Date of this Version

10-1-1998

Comments

Published in INFECTION AND IMMUNITY, Oct. 1998, p. 5031–5035 Vol. 66, No. 10. Copyright © 1998, American Society for Microbiology. Used by permission.

Abstract

Pigs infected with hemolytic F4+ strains of enterotoxigenic Escherichia coli often develop septicemia secondary to intestinal infection. We tested the hypothesis that inactivation of hemolysin would reduce the ability of F4+ enterotoxigenic E. coli to cause septicemia in swine following oral inoculation. Inactivation of the hemolysin structural gene (hlyA) did not decrease the incidence of septicemia in the gnotobiotic piglet model.

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