Veterinary and Biomedical Sciences, Department of


Date of this Version



Daniel GR, Sollars PJ, Pickard GE, Smith GA. 2015. Pseudorabies virus fast axonal transport occurs by a pUS9-independent mechanism. J Virol 89:8088–8091. doi:10.1128/JVI.00771-15.


Copyright © 2015, American Society for Microbiology. All Rights Reserved. Used by permission.


Reactivation from latency results in transmission of neurotropic herpesviruses from the nervous system to body surfaces, referred to as anterograde axonal trafficking. The virus-encoded protein pUS9 promotes axonal dissemination by sorting virus particles into axons, but whether it is also an effector of fast axonal transport within axons is unknown. To determine the role of pUS9 in anterograde trafficking, we analyzed the axonal transport of pseudorabies virus in the presence and absence of pUS9.