824A Hamilton Hall
University of Nebraska-Lincoln
Current research: Our group uses the power of stereocontrolled organic synthesis to address questions in biological chemistry, particularly those related to protein-ligand interactions. For example, Fig. 1 illustrates the first catalytic, asymmetric synthesis of (-)-podophyllotoxin, which serves as a tool us to examine how the structure of the E-ring affects drug binding to tubulin. Total synthesis has yielded compounds more potent than the natural product itself, both in the tubulin assay and against human cancer cell lines.
A Set of Phosphatase-Inert “Molecular Rulers” to Probe for Bivalent Mannose 6-Phosphate Ligand-Receptor Interactions, Xiang Fei, Christopher M. Connelly, Richard G. MacDonald, and David B. Berkowitz
α-Vinylic amino acids: occurrence, asymmetric synthesis, and biochemical mechanisms, David B. Berkowitz, Bradley D. Charette, Kannan Karukurichi, and Jill M. McFadden
Protein Structure Similarity Clustering: Dynamic Treatment of PDB Structures Facilitates Clustering, Bradley D. Charette, Richard G. MacDonald, Stefan Wetzel, David B. Berkowitz, and Herbert Waldmann
In situ enzymatic screening (ISES) of P,N-ligands for Ni(0)- mediated asymmetric intramolecular allylic amination, David B. Berkowitz, Weijun Shen, and Gourhari Maiti