David B. Berkowitz

Professor
824A Hamilton Hall
University of Nebraska-Lincoln

dbb@unlserve.unl.edu

Current research: Our group uses the power of stereocontrolled organic synthesis to address questions in biological chemistry, particularly those related to protein-ligand interactions. For example, Fig. 1 illustrates the first catalytic, asymmetric synthesis of (-)-podophyllotoxin, which serves as a tool us to examine how the structure of the E-ring affects drug binding to tubulin. Total synthesis has yielded compounds more potent than the natural product itself, both in the tubulin assay and against human cancer cell lines.

Follow

2007

PDF

A Set of Phosphatase-Inert “Molecular Rulers” to Probe for Bivalent Mannose 6-Phosphate Ligand-Receptor Interactions, Xiang Fei, Christopher M. Connelly, Richard G. MacDonald, and David B. Berkowitz

2006

PDF

α-Vinylic amino acids: occurrence, asymmetric synthesis, and biochemical mechanisms, David B. Berkowitz, Bradley D. Charette, Kannan Karukurichi, and Jill M. McFadden

PDF

Protein Structure Similarity Clustering: Dynamic Treatment of PDB Structures Facilitates Clustering, Bradley D. Charette, Richard G. MacDonald, Stefan Wetzel, David B. Berkowitz, and Herbert Waldmann

2004

PDF

In situ enzymatic screening (ISES) of P,N-ligands for Ni(0)- mediated asymmetric intramolecular allylic amination, David B. Berkowitz, Weijun Shen, and Gourhari Maiti