The Hyaluronan Receptor for Endocytosis (HARE) Activates NF-κB-mediated Gene Expression in Response to 40–400-kDa, but Not Smaller or Larger, Hyaluronans

Authors

• Madhu S. Pandey, University of Oklahoma Health Sciences Center
• Bruce A. Baggenstoss, University of Oklahoma Health Sciences Center
• Jennifer Washburn, University of Oklahoma Health Sciences Center
• Edward N. Harris, University of Nebraska-LincolnFollow
• Paul H. Weigel, University of Oklahoma Health Sciences CenterFollow

Document Type

Article

Date of this Version

2013

Citation

THE JOURNAL OF BIOLOGICAL CHEMISTRY VOL. 288, NO. 20, pp. 14068–14079, May 17, 2013

Comments

© 2013 by The American Society for Biochemistry and Molecular Biology, Inc.

Abstract

Background: HARE mediates systemic clearance of hyaluronan (HA), which turns over continuously in tissues.

Results: HARE uptake of 40–400-kDa, but not larger or smaller, HA stimulated NF-κB activation.

Conclusion: HA-HARE signal complexes activate NF-κB and gene transcription only with optimally sized HA.

Significance: HARE responsiveness to a narrow size range ofHAdegradation products may be a sensing system to detect tissue ECM stress.