Biochemistry, Department of
Document Type
Article
Date of this Version
2013
Citation
THE JOURNAL OF BIOLOGICAL CHEMISTRY VOL. 288, NO. 20, pp. 14068–14079, May 17, 2013
Abstract
Background: HARE mediates systemic clearance of hyaluronan (HA), which turns over continuously in tissues.
Results: HARE uptake of 40–400-kDa, but not larger or smaller, HA stimulated NF-κB activation.
Conclusion: HA-HARE signal complexes activate NF-κB and gene transcription only with optimally sized HA.
Significance: HARE responsiveness to a narrow size range ofHAdegradation products may be a sensing system to detect tissue ECM stress.
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Comments
© 2013 by The American Society for Biochemistry and Molecular Biology, Inc.