Biochemistry, Department of

 

Document Type

Article

Date of this Version

2013

Citation

THE JOURNAL OF BIOLOGICAL CHEMISTRY VOL. 288, NO. 20, pp. 14068–14079, May 17, 2013

Comments

© 2013 by The American Society for Biochemistry and Molecular Biology, Inc.

Abstract

Background: HARE mediates systemic clearance of hyaluronan (HA), which turns over continuously in tissues.

Results: HARE uptake of 40–400-kDa, but not larger or smaller, HA stimulated NF-κB activation.

Conclusion: HA-HARE signal complexes activate NF-κB and gene transcription only with optimally sized HA.

Significance: HARE responsiveness to a narrow size range ofHAdegradation products may be a sensing system to detect tissue ECM stress.

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