MicroRNA Function in Human Diseases

Authors

Sathish Kumar Natarajan, University of Nebraska - LincolnFollow
Mary Anne Smith, University of Nebraska Medical Center
Cody J. Wehrkamp, University of Nebraska Medical Center
Ashley M. Mohr, University of Nebraska Medical Center
Justin L. Mott, University of Nebraska Medical Center

Document Type

Article

Date of this Version

2013

Citation

Med Epigenet 2013;1:106–115

Comments

Open Access article

Abstract

MicroRNAs are emerging as a hot topic in research, and rightfully so. They show great promise as targets of treatment and as markers for common human diseases, such as cancer and metabolic diseases. In this review, we address some of the basic questions regarding micro- RNA function in human disease and the clinical significance of microRNAs. Specifically, micro- RNAs in epigenetics, cancer, and metabolic diseases are discussed, with examples taken from cholangiocarcinoma and nonalcoholic fatty liver disease.