Department Chair
551/829 Hamilton Hall
University of Nebraska-Lincoln
Lincoln, Nebraska 68588 United States
patrick.dussault@unl.edu
We conduct research in a number of areas, all involving organic synthesis as either a tool or an objective.
Dussault Research Group website: https://chem.unl.edu/dussault-group
2019
OPTICAL SENSING AND SEPARATION BASED ON ORDERED 3D NANOSTRUCTURED SURFACES, Mathias M. Schubert, Tino Hofmann, Daniel Schmidt, Patrick H. Dussault, Andrea Holmes, and Rebecca Y. Lai
Novel Amphiphilic Cyclobutene and Cyclobutane cis-C18 Fatty Acid Derivatives Inhibit Mycobacterium avium subsp. paratuberculosis Growth, Denise K. Zinniel, Wantanee Sittiwong, Darrell D. Marshall, Govardhan Rathnaiah, Isin T. Sakallioglu, Robert Powers, Patrick H. Dussault, and Raul G. Barletta
2018
Reductive Cleavage of Organic Peroxides by Iron Salts and Thiols, Anderw Olson, Abigail J. Jameson, Shiva K. Kyasa, Boone W. Evans, and Patrick H. Dussault
2017
SELF-ASSEMBLED MONOLAYERS AND METHODS FOR USING THE SAME IN BIOSENSING APPLICATIONS, Patrick Dussault, Rebecca Lai, Thomas J. Fisher, and Anita J. Zaitouna
OPTICAL SENSING AND SEPARATION BASED ON ORDERED THREE-DIMENSIONAL NANOSTRUCTURED SURFACES, Mathias Schubert, Tino Hofmann, Daniel Schmidt, Patrick H. Dussault, Andrea Homes, and Rebecca Lai
2015
Dietary Plant Sterol Esters Must Be Hydrolyzed to Reduce Intestinal Cholesterol Absorption in Hamsters, Trevor J. Carden, Jiliang Hang, Patrick Dussault, and Timothy P. Carr
Fatty Acyl Incorporation in the Biosynthesis of WAP-8294A, a Group of Potent Anti-MRSA Cyclic Lipodepsipeptides, Haotong Chen, Andrew S. Olson, Wei Su, Patrick Dussault, and Liangcheng Du
SELF-ASSEMBLED MONOLAYERS AND METHODS FOR USING THE SAME IN BIOSENSING APPLICATIONS, Patrick H. Dussault, Rebecca Lai, Thomas J. Fisher, and Anita J. Zaitouna
A Dedicated Type II NADPH Dehydrogenase Performs the Penultimate Step in the Biosynthesis of Vitamin K1 in Synechocystis and Arabidopsis, Abdelhak Fatihi, Scott Latimer, Stefan Schmollinger, Anna Block, Patrick Dussault, Wim F.J. Vermaas, Sabeeha S. Merchant, and Gilles J. Basset
Synthesis of Ethers via Reaction of Carbanions and Monoperoxyacetals, ShivaKumar Kyasa, Rebecca N. Meier, Ruth A. Pardini, Tristan K. Truttmann, Keith T. Kuwata, and Patrick Dussault
Synthesis of a 2,4,6,8,10-dodecapentanoic acid thioester as a substrate for biosynthesis of heat stable antifungal factor (HSAF), Andrew S. Olson, Haotong Chen, Liangcheng Du, and Patrick Dussault
2014
β-Keto and β-hydroxyphosphonate analogs of biotin-5’-AMP are inhibitors of holocarboxylase synthetase, Wantanee Sittiwong, Elizabeth Cordonier, Janos Zempleni, and Patrick Dussault
Development of cyclobutene- and cyclobutane-functionalized fatty acids with inhibitory activity against Mycobacterium tuberculosis, Wantanee Sittiwong, Denise Zinniel, Robert J. Fenton, Darrel Marshall, Courtney B. Story, Bohkyung Kim, Ji-Young Lee, Robert Powers, Raul G. Barletta, and Patrick Dussault
Oxacycle Synthesis via Intramolecular Reaction of Carbanions and Peroxides, Rachel Willand-Charnley, Benjamin W. Puffer, and Patrick Dussault
2013
Design and Synthesis of a New Class of Twin-Chain Amphiphiles for Self-Assembled Monolayer-based Electrochemical Biosensor Applications, Thomas J. Fisher, Socrates Jose P. Cañete, Rebecca Lai, and Patrick Dussault
Synthesis Of Alkyl Hydroperoxides Via Alkylation Of gem-Dihydroperoxides, ShivaKumar Kyasa, Benjamin W. Puffer, and Patrick Dussault
Re2O7-catalyzed reaction of hemiacetals and aldehydes with O-, S-, and C-nucleophiles, Wantanee Sittiwong, Michael W. Richardson, Charles E. Schiaffo, Thomas J. Fisher, and Patrick Dussault
Re2O7-catalyzed reaction of hemiacetals and aldehydes with O-, S-, and C-nucleophiles, Wantanee Sittiwong, Michael W. Richardson, Charles E. Schiaffo, Thomas J. Fisher, and Patrick H. Dussault
Tandem application of C-C bond-forming reactions with reductive ozonolysis, Rachel Willand-Charnley and Patrick Dussault
2012
Regioselective Synthesis of Tetraalkynylarenes by Consecutive Dual Sonogashira Coupling Reactions of the Bis(triflate) of 4,5-Diiodobenzene-1,2-diol, Thomas J. Fisher and Patrick H. Dussault
Generation of singlet oxygen from fragmentation of monoactivated 1,1-dihydroperoxides, Jiliang Hang, Prasanta Ghorai, Solaire A. Finkenstaedt-Quinn, Ilhan Findik, Emily Sliz, Keith T. Kuwata, and Patrick Dussault
In vitro and in vivo activity of 3-alkoxy-1,2- dioxolanes against Schistosoma mansoni, Katrin Ingram, Charles E. Schiaffo, Wantanee Sittiwong, Evan Benner, Patrick Dussault, and Jennifer Keiser
Pyridine is an organocatalyst for the reductive ozonolysis of alkenes, Rachel Willand-Charnley, Thomas J. Fisher, Bradley M. Johnson, and Patrick Dussault
2011
Phytosterol stearate esters elicit similar responses on plasma lipids and cholesterol absorption but different responses on fecal neutral sterol excretion and hepatic free cholesterol in male Syrian hamsters, Mark M. Ash, Jiliang Hang, Patrick Dussault, and Timothy P. Carr
Reversible collapse of the Langmuir films of a series of triphenylsilyl ether-terminated amphiphiles, Christine A. DeVries, James J. Haycraft, Qiang Han, Farhana Noor-e-Ain, Joseph Raible, Patrick Dussault, and Craig J. Eckhardt
N5-Phosphonoacetyl-L-ornithine (PALO): A convenient synthesis and investigation of influence on regulation of amino acid biosynthetic genes in Saccharomyces cerevisiae, Brad Johnson, Rachel Steadman, Krista D. Patefield, Jeffrey J. Bunker, Audrey L. Atkin, and Patrick Dussault
A Mild One-Pot Conversion of Alkenes into Amines through Tandem Ozonolysis and Reductive Amination, ShivaKumar Kyasa, Thomas J. Fisher, and Patrick Dussault
Biosynthesis of HSAF, a Tetramic Acid-containing Macrolactam from Lysobacter enzymogenes, Lili Lou, Guoliang Qian, Yunxuan Xie, Jiliang Hang, Haotong Chen, Kathia Zaleta- Rivera, Yaoyao Li, Yuemao Shen, Patrick Dussault, Fengquan Liu, and Liangcheng Du
3-Alkoxy-1,2-Dioxolanes: Synthesis and Evaluation as Potential Antimalarial Agents, Charles E. Schiaffo, Matthias Rottman, Sergio Wittlin, and Patrick Dussault
2010
Plant sterol and stanol substrate specificity of pancreatic cholesterol esterase, Andrew W. Brown, Jiliang Hang, Patrick H. Dussault, and Timothy P. Carr
Fragmentation of chloroperoxides: Hypochlorite-mediated dehydration of hydroperoxyacetals to esters, Thomas J. Fisher and Patrick Dussault
A concise synthesis of β-sitosterol and other phytosterols, Jiliang Hang and Patrick Dussault
Efficient synthesis and conformational investigations of cis-pentacenediols, Jinyue Jiang, Charles E. Schiaffo, Chris P. Schwartz, Yong Pei, Joseph J. Dumais, Xiao Cheng Zeng, Patrick Dussault, and Li Tan
B(C6F5)3-promoted tandem silylation and intramolecular hydrosilylation: diastereoselective synthesis of oxasilinanes and oxasilepanes, Roman Shchepin, Chunping Xu, and Patrick Dussault
2009
A new peroxide fragmentation: efficient chemical generation of 1O2 in organic media, Patrick Dussault and Prasanta Ghorai
Spiroadamantyl 1,2,4-trioxolane, 1,2,4-trioxane, and 1,2,4-trioxepane pairs: Relationship between peroxide bond iron(II) reactivity, heme alkylation efficiency, and antimalarial activity, Xiaofang Wang, Darren J. Creek, Charles E. Schiaffo, Yuxiang Dong, Jacques Chollet, Christian Scheurer, Segio Wittlin, Susan A. Charman, Patrick Dussault, James K. Wood, and Jonathan L. Vennerstrom
Asymmetric synthesis of 1,2-dioxanes: Approaches to the peroxyplakoric acids, Chunping Xu, Chris Schwartz, Joseph Raible, and Patrick Dussault
2008
Influence of heterocyclic and oxime-containing farnesol analogs on quorum sensing and pathogenicity in Candida albicans, Roman Shchepin, Dhammika H.M.L.P. Navarathna, Raluca Dumitru, Shane Lippold, Kenneth W. Nickerson, and Patrick Dussault
2007
Cholesterol-lowering properties of plant sterols esterified with beef tallow fatty acids in hamsters, David M. Guderian Jr., Heather E. Rasmussen, Curtis A. Wray, Patrick Dussault, and Timothy P. Carr
2006
Reduction in Cholesterol Absorption Is Enhanced by Stearate-Enriched Plant Sterol Esters in Hamsters, Heather E. Rasmussen, David M. Guderian Jr., Curtis A. Wray, Patrick H. Dussault, Vicki L. Schlegel, and Timothy P. Carr
“Reductive ozonolysis” via a new fragmentation of carbonyl oxides, Chris Schwartz, Joseph Raible, Kyle Mott, and Patrick Dussault
A Bidomain Nonribosomal Peptide Synthetase Encoded by FUM14 Catalyzes the Formation of Tricarballylic Esters in the Biosynthesis of Fumonisins, Kathia Zaleta-Rivera, Chunping Xu, Fengan Yu, Robert A. E. Butchko, Robert H. Proctor, Maria E. Hidalgo-Lara, Ashraf S. Raza, Patrick Dussault, and Liangcheng Du
2005
Stereoselective allylation of chiral monoperoxyacetals, Aqeel Ahmed and Patrick Dussault
Biologically Active Fluorescent Farnesol Analogs, Roman Shchepin, Razvan Dumitru, Kenneth W. Nickerson, Miranda Lund, and Patrick Dussault
2004
Magnesium/Methanol: An Effective Reducing Agent for Peroxides , Peng Dai, Patrick Dussault, and Tony K. Trullinger
Curtius rearrangement and Wolff homologation of functionalized peroxides, Patrick Dussault and Chunping Xu
2003
Quorum Sensing in Candida albicans: Probing Farnesol’s Mode of Action with 40 Natural and Synthetic Farnesol Analogs, Roman Shchepin, Jacob M. Hornby, Erin Burger, Timothy Niessen, Patrick H. Dussault, and Kenneth Nickerson
2001
Quorum Sensing in the Dimorphic Fungus Candida albicans Is Mediated by Farnesol, Jacob M. Hornby, Ellen C. Jensen, Amber C. Lisec, Joseph J. Tasto, Brandon Jahnke, Richard Shoemaker, Patrick Dussault, and Kenneth W. Nickerson
1998
Metathesis-based synthesis of jasmonate and homojasmonate lactones, candidates for extracellular quorum sensing molecules in Candida albicans, Su C. Cho, Patrick Dussault, Amber D. Lisec, Ellen C. Jensen, and Kenneth W. Nickerson