Robert Powers, Ph.D
University of Nebraska Lincoln
Department of Chemistry
722 Hamilton Hall
Lincoln, NE 68588-0304

(402) 472-3039 fax: (402) 472-2044
email: rpowers3@unl.edu
http://bionmr-c1.unl.edu/

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2017

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Amino Acid Catabolism in Staphylococcus aureus and the Function of Carbon Catabolite Repression, Cortney R. Halsey, Shulei Lei, Jacqueline K. Wax, Mckenzie K. Lehman, Austin S. Nuxoll, Laurey Steinke, Marat Sadykov, Robert Powers, and Paul D. Fey

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Metabolic Investigations of the Molecular Mechanisms Associated with Parkinson’s Disease, Robert Powers, Shulei Lei, Annadurai Anandhan, Darrell D. Marshall, Bradley Worley, Ronald Cerny, Eric D. Dodds, Yuting Huang, Mihalis I. Panayiotidis, Aglaia Pappa, and Rodrigo Franco

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REVIEW: New frontiers in metabolomics: from measurement to insight, Eli Riekeberg and Robert Powers

2016

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PCA as a practical indicator of OPLS-DA model reliability, Bradley Worley and Robert Powers

2015

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Staphylococcus aureus Metabolic Adaptations during the Transition from a Daptomycin Susceptibility Phenotype to a Daptomycin Nonsusceptibility Phenotype, Rosmarie Gaupp, Shulei Lei, Joseph M. Reed, Henrik Peisker, Susan Boyle- Vavra, Arnold S. Bayer, Markus Bischoff, Mathias Herrmann, Robert S. Daum, R. D. Powell, and Greg A. Somerville

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Combining DI-ESI–MS and NMR datasets for metabolic profiling, Darrell D. Marshall, Shulei Lei, Bradley Worley, Yuting Huang, Aracely Garcia- Garcia, Rodrigo Franco, Eric D. Dodds, and Robert Powers

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A Sequential Algorithm for Multiblock Orthogonal Projections to Latent Structures, Bradley Worley and Robert Powers

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Deterministic Multidimensional Nonuniform Gap Sampling, Bradley Worley and Robert Powers

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Generalized adaptive intelligent binning of multiway data, Bradley Worley and Robert Powers

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Statistical Removal of Background Signals from High-throughput 1H NMR Line-broadening Ligand-affinity Screens, Bradley Worley, Nicholas J. Sisco, and Robert Powers

2014

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Metabolomics Analysis Identifies D-Alanine-D-alanine Ligase as the Primary Lethal Target of D-cycloserine in Mycobacteria, Steven M. Halouska, Robert J. Fenton, Denise K. Zinniel, Darrell D. Marshall, Raul G. Barletta, and Robert Powers

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Alterations in Energy/Redox Metabolism Induced by Mitochondrial and Environmental Toxins: A Specific Role for Glucose-6-Phosphate- Dehydrogenase and the Pentose Phosphate Pathway in Paraquat Toxicity, Shulei Lei, Laura Zavala- Flores, Aracely Garcia- Garcia, Renu Nandakumar, Yuting Huang, Nandakumar Madayiputhiya, Robert C. Stanton, Eric D. Dodds, Robert Powers, and Rodrigo Franco

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Identification of low molecular weight compounds inhibiting growth of Corynebacteria: potential lead compounds for antibiotics, Jaime L. Patera, Jennifer C. Copeland, Alexander Eletsky, Greg A. Somerville, Thomas Szyperski, and Robert Powers

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The Current State of Drug Discovery and a Potential Role for NMR Metabolomics, Robert Powers

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Metabolic reprogramming induced by ketone bodies diminishes pancreatic cancer cachexia, Surendra K. Shukla, Teklab Gebregiworgis, Vinee Purohit, Nina V. Chaika, Venugopal Gunda, Prakash Radhakrishnan, Kamiya Mehla, Iraklis I. Pipinos, Robert Powers, Fang Yu, and Pankaj K. Singh

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Correction: Metabolic reprogramming induced by ketone bodies diminishes pancreatic cancer cachexia, Surendra K. Shukla, Teklab Gebregiworgis, Vinee Purohit, Nina V. Chaika, Venugopal Gunda, Prakash Radhakrishnan, Kamiya Mehla, Iraklis I. Pipinos, Robert Powers, Fang Yu, and Pankaj K. Singh

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Development of cyclobutene- and cyclobutane-functionalized fatty acids with inhibitory activity against Mycobacterium tuberculosis, Wantanee Sittiwong, Denise Zinniel, Robert J. Fenton, Darrel Marshall, Courtney B. Story, Bohkyung Kim, Ji-Young Lee, Robert Powers, Raul G. Barletta, and Patrick Dussault

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Identification of low molecular weight compounds inhibiting growth of Corynebacteria: potential lead compounds for antibiotics, Jaime L. Stark, Jennifer C. Copeland, Alexander Eletsky, Greg A. Somerville, Thomas Szyperski, and Robert Powers

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Structure and Function of Human DnaJ Homologue Subfamily A Member 1 (DNAJA1) and Its Relationship to Pancreatic Cancer, Jaime L. Stark, Kamiya Mehla, Nina V. Chaika, Thomas B. Acton, Rong Xiao, Pankaj K. Singh, Gaetano T. Montelione, and Robert Powers

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MVAPACK: A Complete Data Handling Package for NMR Metabolomics, Bradley Worley and Robert Powers

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Simultaneous Phase and Scatter Correction for NMR Datasets, Bradley Worley and Robert Powers

2013

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The potential of urinary metabolites for diagnosing multiple sclerosis, Teklab Gebregiworgis, Chandirasegara Massilamany, Arunakumar Gangaplara, Sivasubramani Thulasingam, Venkata Kolli, Mark T. Werth, Eric D. Dodds, David Steffen, Jay Reddy, and Robert Powers

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Revisiting Protocols for the NMR Analysis of Bacterial Metabolomes, Steven M. Halouska, Bo Zhang, Rosmarie Gaupp, Shulei Lei, Emily Snell, Robert J. Fenton, Raul G. Barletta, Greg A. Somerville, and Robert Powers

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Catabolite Control Protein E (CcpE) Is a LysR-type Transcriptional Regulator of Tricarboxylic Acid Cycle Activity in Staphylococcus aureus, Torsten Hartmann, Bo Zhang, Grégory Baronian, Bettina Schulthess, Dagmar Homerova, Stephanie Grubmuller, Erika Kutzner, Rosmarie Gaupp, Ralph Bertram, Robert Powers, Karen M. Eisenreich, Jan Kormanec, Mathias Herrmann, Virginie Molle, Greg A. Somerville, and Markus Bischoff

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NMR Metabolomics Analysis of Parkinson's Disease, Shulei Lei and Robert Powers

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Inactivation of the Pta-AckA Pathway Causes Cell Death in Staphylococcus aureus, Marat R. Sadykov, Vinai C. Thomas, Darrell D. Marshall, Christopher J. Wenstrom, Derek E. Moormeier, Todd J. Widhelm, Austin S. Nuxoll, Robert Powers, and Kenneth W. Bayles

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Utilities for Quantifying Separation in PCA/PLS-DA Scores Plots, Bradley Worley, Steven M. Halouska, and Robert Powers

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Multivariate Analysis in Metabolomics, Bradley Worley and Robert Powers

2012

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MUC1 mucin stabilizes and activates hypoxia-inducible factor 1 alpha to regulate metabolism in pancreatic cancer, Nina V. Chaika, Teklab Gebregiworgis, Michelle E. Lewallen, Vinee Purohit, Prakash Radhakrishnan, Xiang Liu, Bo Zhang, Kamiya Mehla, Roger B. Brown, Thomas Caffrey, Fang Yu, Keith R. Johnson, Robert Powers, Michael A. Hollingsworth, and Pankaj K. Singh

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Predicting the in vivo Mechanism of Action for Drug Leads using NMR Metabolomics, Steven M. Halouska, Robert J. Fenton, Raúl G. Barletta, and Robert Powers

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Analysis of bacterial biofilms using NMR-based metabolomics, Bo Zhang and Robert Powers

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Sample Preparation of Mycobacterium tuberculosis Extracts for Nuclear Magnetic Resonance Metabolomic Studies, Denise Zinniel, Robert J. Fenton, Steven M. Halouska, Robert Powers, and Raul G. Barletta

2011

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Research in bioanalysis and separations at the University of Nebraska – Lincoln, David S. Hage, Eric D. Dodds, Liangcheng Du, and Robert Powers

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Searching the protein structure database for ligand-binding site similarities using CPASS v.2, Robert Powers, Jennifer C. Copeland, Jaime L. Stark, Adam Caprez, Ashu Guru, and David R. Swanson

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A Correlation between Protein Function and Ligand Binding Profiles, Matthew D. Shortridge, Michael Bokemper, Jennifer C. Copeland, Jaime L. Stark, and Robert Powers

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Bacterial Protein Structures Reveal Phylum Dependent Divergence, Matthew D. Shortridge, Thomas Triplet, Peter Revesz, Mark A. Griep, and Robert Powers

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NMR Analysis of a Stress Response Metabolic Signaling Network, Bo Zhang, Steven M. Halouska, Charles E. Schiaffo, Marat R. Sadykov, Greg A. Somerville, and Robert Powers

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An Inexpensive High-Throughput NMR Tube Cleaning Apparatus, Bo Zhang, James Hodgson, Walter Hancock, and Robert Powers

2010

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Using NMR Metabolomics to Investigate Tricarboxylic Acid Cycle-dependent Signal Transduction in Staphylococcus epidermidis, Marat R. Sadykov, Bo Zhang, Steven M. Halouska, Jennifer L. Nelson, Lauren W. Kreimer, Yefei Zhu, Robert Powers, and Greg A. Somerville

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Solution structure and function of YndB, an AHSA1 protein from Bacillus subtilis, Jaime L. Stark, Kelly A. Mercier, Geoffrey A. Mueller, Thomas B. Acton, Rong Xiao, Gaetano T. Montelione, and Robert Powers

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PROFESS: a PROtein Function, Evolution, Structure and Sequence database, Thomas Triplet, Matthew D. Shortridge, Mark A. Griep, Jaime L. Stark, Robert Powers, and Peter Revesz

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Analysis of Metabolomic PCA Data using Tree Diagrams, Mark T. Werth, Steven M. Halouska, Matthew D. Shortridge, Bo Zhang, and Robert Powers

2009

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Solution Structure of the Pseudomonas putida protein PpPutA45 and its DNA Complex, Steven M. Halouska, Yuzhen Zhou, Donald F. Becker, and Robert Powers

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Structure and function of Pseudomonas aeruginosa protein PA1324 (21–170), Kelly A. Mercier, John R. Cort, Michael A. Kennedy, Erin E. Lockert, Shuisong Ni, Matthew D. Shortridge, and Robert Powers

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1H, 13C, and 15N NMR assignments for the Bacillus subtilis yndB START domain, Kelly A. Mercier, Geoffrey A. Mueller, Thomas B. Acton, Rong Xiao, Gaetano T. Montelione, and Robert Powers

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Unique opportunities for NMR methods in structural genomics, Gaetano T. Montelione, Cheryl Arrowsmith, Mark E. Girvin, Michael A. Kennedy, John L. Markley, Robert Powers, James H. Prestegard, and Thomas Szyperski

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Advances in Nuclear Magnetic Resonance for Drug Discovery, Robert Powers

2008

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The Application of FAST-NMR for the Identification of Novel Drug Discovery Targets, Robert Powers, Kelly A. Mercier, and Jennifer C. Copeland

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Tricarboxylic Acid Cycle-Dependent Regulation of Staphylococcus epidermidis Polysaccharide Intercellular Adhesin Synthesis, Marat R. Sadykov, Michael E. Olson, Steven M. Halouska, Yefei Zhu, Paul D. Fey, Robert Powers, and Greg A. Somerville

2007

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Use of NMR Metabolomics to Analyze the Targets of D-cycloserine in Mycobacteria: Role of D-Alanine Racemase, Steven M. Halouska, Ofelia Chacon, Robert J. Fenton, Denise K. Zinniel, Raul G. Barletta, and Robert Powers

2006

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List of Publications: Robert Powers

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Negative impact of noise on the principal component analysis of NMR data, Steven M. Halouska and Robert Powers

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A topology-constrained distance network algorithm for protein structure determination from NOESY data, Yuanpeng Janet Huang, Roberto Tejero, Robert Powers, and Gaetano T. Montelione

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FAST-NMR - Functional Annotation Screening Technology Using NMR Spectroscopy, Kelly A. Mercier, Michael Baranski, Viswanathan Ramanathan, Peter Z. Revesz, Rong Xiao, Gaetano T. Montelione, and Robert Powers

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Comparison of Protein Active Site Structures for Functional Annotation of Proteins and Drug Design, Robert Powers, Jennifer C. Copeland, Katherine Germer, Kelly A. Mercier, Viswanathan Ramanathan, and Peter Revesz

2005

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Determining the optimal size of small molecule mixtures for high throughput NMR screening, Kelly A. Mercier and Robert Powers

Solution structure of Archaeglobus fulgidis peptidyl-tRNA hydrolase (Pth2) provides evidence for an extensive conserved family of Pth2 enzymes in archea, bacteria, and eukaryotes, Robert Powers, Nebojsa Mirkovic, Sharon Goldsmith-Fischman, Thomas B. Acton, Yi-wen Chiang, Yuanpeng J. Huang, LiChung Ma, P. K. Rajan, John R. Cort, Michael A. Kennedy, Jinfeng Liu, Burkhard Rost, Barry Honig, Diana Murray, and Gaetano T. Montelione

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Using Databases and Computational Techniques to Infer the Function of Novel Proteins, Viswanathan Ramanathan, Kelly A. Mercier, Robert Powers, and Peter Revesz

2004

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1H, 13C, and 15N assignments for the Archaeglobus fulgidis protein AF2095, Robert Powers, Thomas B. Acton, Yi-wen Chiang, P. K. Rajan, John R. Cort, Michael A. Kennedy, Jinfeng Liu, LiChung Ma, Burkhard Rost, and Gaetano T. Montelione

2002

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Applications of NMR to structure-based drug design in structural genomics, Robert Powers

2001

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Solution Structure of B. subtilis Acyl Carrier Protein, Guang-Yi Xu, Amy Tam, Laura Lin, Jeffrey Hixon, Christian C. Fritz, and Robert Powers

2000

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Structural Relatedness of Distinct Determinants Recognized by Monoclonal Antibody TP25.99 on ß2-Microglobulin-Associated and ß2-Microglobulin-Free HLA Class I Heavy Chains, Smruti A. Desai, Xinhui Wang, Elvyra J. Noronha, Qinwei Zhou, Vera Rebmann, Hans Grosse-Wilde, Franklin J. Moy, Robert Powers, and Soldano Ferrone

1995

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1H, 15N, 13C and 13CO Assignments and Secondary Structure Determination of Basic Fibroblast Growth Factor Using 3D Heteronuclear NMR Spectroscopy, Franklin J. Moy, Andrew P. Seddon, Ernest B. Campbell, Peter Böhlen, and Robert Powers

1993

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Relationships between the Precision of High-Resolution Protein NMR Structures, Solution-Order Parameters, and Crystallographic B Factors, Robert Powers, G. Marius Clore, Daniel S. Garrett, and Angela M. Gronenborn

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The High-Resolution, Three-Dimensional Solution Structure of Human Interleukin-4 Determined by Multidimensional Heteronuclear Magnetic Resonance Spectroscopy, Robert Powers, Daniel S. Garrett, Carl J. March, Eric A. Frieden, Angela M. Gronenborn, and G. Marius Clore

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Increased Resolution and Improved Spectral Quality in Four-Dimensional 13C/13C-Separated HMQC-NOESY-HMQC Spectra Using Pulsed Field Gradients, Geerten W. Vuister, G. Marius Clore, Angela M. Gronenborn, Robert Powers, Daniel S. Garrett, Rolf Tschudin, and Ad Bax

1992

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Determination of the Secondary Structure and Folding Topology of Human Interleukin-4 Using Three-Dimensional Heteronuclear Magnetic Resonance Spectroscopy, Daniel S. Garrett, Robert Powers, Carl J. March, Eric A. Frieden, G. Marius Clore, and Angela M. Gronenborn

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Analysis of the Backbone Dynamics of the Ribonuclease H Domain of the Human Immunodeficiency Virus Reverse Transcriptase Using 15N Relaxation Measurements, Robert Powers, G. Marius Clore, Stephen J. Stahl, Paul T. Wingfield, and Angela Gronenborn

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1H, 15N, 13C, and 13CO Assignments of Human Interleukin-4 Using Three-Dimensional Double- and Triple-Resonance Heteronuclear Magnetic Resonance Spectroscopy, Robert Powers, Daniel S. Garrett, Carl J. March, Eric A. Frieden, Angela M. Gronenborn, and G. Marius Clore

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Three-Dimensional Solution Structure of Human Interleukin-4 by Multidimensional Heteronuclear Magnetic Resonance Spectroscopy, Robert Powers, Daniel S. Garrett, Carl J. March, Eric A. Frieden, Angela M. Gronenborn, and G. Marius Clore

1991

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A Common Sense Approach to Peak Picking in Two-, Three-, and Four-Dimensional Spectra Using Automatic Computer Analysis of Contour Diagrams, Daniel S. Garrett, Robert Powers, Angela M. Gronenborn, and G. Marius Clore

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Secondary Structure of the Ribonuclease H Domain of the Human Immunodeficiency Virus Reverse Transcriptase in Solution using Three-Dimensional Double and Triple Resonance Heteronuclear Magnetic Resonance Spectroscopy, Robert Powers, G. Marius Clore, Ad Bax, Daniel S. Garrett, Stephen J. Stahl, Paul T. Wingfield, and Angela M. Gronenborn

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Three-Dimensional Triple-Resonance NMR of 13C/15N-Enriched Proteins Using Constant-Time Evolution, Robert Powers, Angela M. Gronenborn, G. Marius Clore, and Ad Bax

1990

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Two-Dimensional 1H and 31P NMR Spectra and Restrained Molecular Dynamics Structure of an Oligodeoxyribonucleotide Duplex Refined via a Hybrid Relaxation Matrix Procedure, Robert Powers, Claude R. Jones, and David G. Gorenstein

1989

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Two-Dimensional 1H and 31P NMR Spectra of a Decamer Oligodeoxyribonucleotide Duplex and a Quinoxaline ([MeCys3, MeCys7]TANDEM) Drug Duplex Complex, Robert Powers, Richard K. Olsen, and David G. Gorenstein