Chemical and Biomolecular Engineering, Department of
Department of Chemical and Biomolecular Engineering: Faculty Publications
2016
A scalable low-cost cGMP process for clinical grade production of the HIV inhibitor 5P12-RANTES in Pichia pastoris, Fabrice Cerini, Hubert Gaertner, Knut Madden, Ilya Tolstorukov, Scott Brown, Bram Laukens, Nico Callewaert, Jay C. Harner, Anna M. Oommen, John T. Harms, Anthony R. Sump, Robert C. Sealock, Dustin J. Peterson, Scott K. Johnson, Stephan B. Abramson, Michael M. Meagher, Robin Offord, and Oliver Hartley
Hyaluronic acid-conjugated liposome nanoparticles for targeted delivery to CD44 overexpressing glioblastoma cells, Stephen L. Hayward, Christina L. Wilson, and Srivatsan Kidambi
Noninvasive Measurement of Electrical Events Associated with a Single Chlorovirus Infection of a Microalgal Cell, Seung-Woo Lee, Eun-Hee Lee, Gerhard Thiel, James L. Van Etten, and Ravi Saraf
Scalable Production of Glioblastoma Tumor-initiating Cells in 3 Dimension Thermoreversible Hydrogels, Qiang Li, Haishuang Lin, Ou Wang, Xuefeng Qiu, Srivatsan Kidambi, Loic P. Deleyrolle, Brent A. Reynolds, and Yuguo Lei
Decoy receptor DcR1 is induced in a p50/Bcl3-dependent manner and attenuates the efficacy of temozolomide, Nassir M. Mansour, Giovanna M. Bernal, Longtao Wu, Clayton D. Crawley, Kirk E. Cahill, David J. Voce, Irina V. Balyasnikova, Wei Zhang, Ruben Spretz, Luis Nunez, Gustavo F. Larsen, Ralph R. Weichselbaum, and Bakhtiar Yamini
Methanol and Dimethyl Ether from Renewable Hydrogen and Carbon Dioxide: Alternative Fuels Production and Life-cycle Assessment, Michael J. Matzen and Yaşar Demirel
Characterization of IXINITY (Trenonacog Alfa), a Recombinant Factor IX with Primary Sequence Corresponding to the Threonine-148 Polymorph, Dougald M. Monroe, Richard J. Jenny, Kevin E. Van Cott, Shelly Buhay, and Laura L. Saward
Retargeting the Clostridium botulinum C2 toxin to the neuronal cytosol, Benjamin J. Pavlik, Elizabeth J. Hruska, Kevin E. Van Cott, and Paul H. Blum
Diurnal Regulation of Cellular Processes in the Cyanobacterium Synechocystis sp. Strain PCC 6803: Insights from Transcriptomic, Fluxomic, and Physiological Analyses, Rajib Saha, Deng Liu, Allison Hoynes-O’Connor, Michelle Liberton, Jingjie Yu, Maitrayee Bhattacharyya-Pakrasi, Andrea Balassy, Fuzhong Zhang, Tae Seok Moon, Costas D. Maranas, and Himadri B. Pakrasi
Astrogliosis in a dish: Substrate stiffness induces astrogliosis in primary rat astrocytes, Christina L. Wilson, Stephen L. Hayward, and Srivatsan Kidambi
2015
Energy Intensity and Environmental Impact Metrics of the Back-end Separation of Ethylene Plant by Thermodynamic Analysis, Mahdi H. Alhajji and Yaşar Demirel
Cyanobacterial Alkanes Modulate Photosynthetic Cyclic Electron Flow to Assist Growth under Cold Stress, Bertram M. Berla, Rajib Saha, Costas D. Maranas, and Himadri B. Pakrasi
Breast Cancer/Stromal Cells Coculture on Polyelectrolyte Films Emulates Tumor Stages and miRNA Profiles of Clinical Samples, Amita Daverey, Karleen M. Brown, and Srivatsan Kidambi
Physical Intimacy of Breast Cancer Cells with Mesenchymal Stem Cells Elicits Trastuzumab Resistance through Src Activation, Amita Daverey, Allison P. Drain, and Srivatsan Kidambi
Global Proteomic Analysis Reveals an Exclusive Role of Thylakoid Membranes in Bioenergetics of a Model Cyanobacterium, Michelle Liberton, Rajib Saha, Jon M. Jacobs, Amelia Y. Nguyen, Marina A. Gritsenko, Richard D. Smith, David W. Koppenaal, and Himadri B. Pakrasi
Chemical Storage of Wind Energy by Renewable Methanol Production: Feasibility Analysis Using a Multi-criteria Decision Matrix, Michael J. Matzen, Mahdi H. Alhajji, and Yaşar Demirel
Technoeconomics and Sustainability of Renewable Methanol and Ammonia Productions Using Wind Power-based Hydrogen, Michael J. Matzen, Mahdi H. Alhajji, and Yaşar Demirel
Substrate stiffness regulates primary hepatocyte functions†, Vaishaali Natarajan, Eric J. Berglund, Dorothy X. Chen, and Srivatsan Kidambi
Titanium Dioxide Nanoparticles Trigger Loss of Function and Perturbation of Mitochondrial Dynamics in Primary Hepatocytes, Vaishaali Natarajan, Christina L. Wilson, Stephen L. Hayward, and Srivatsan Kidambi
The Taurine Biosynthetic Pathway of Microalgae, Rahul Tevatia, James Allen, Deepak Rudrappa, Derrick White, Thomas E. Clemente, Heriberto Cerutti, Yaşar Demirel, and Paul H. Blum
Growth factor and ultrasound-assisted bioreactor synergism for human mesenchymal stem cell chondrogenesis, Sanjukta Guha Thakurta, Gaurav Budhiraja, and Anuradha Subramanian
Quantifying Vitamin K-dependent Holoprotein Compaction caused by differential γ-carboxylation using HPSEC, Nicholas C. Vanderslice, Amanda S. Messer, Kanagasabai Vadivel, S. Paul Bajaj, Martin Phillips, Mostafa Fatemi, Weijie Xu, and William H. Velander
Mitochondrial dysfunction and loss of glutamate uptake in primary astrocytes exposed to titanium dioxide nanoparticles, Christina L. Wilson, Vaishaali Natarajan, Stephen L. Hayward, Oleh Khalimonchuk, and Srivatsan Kidambi
Engineering protein processing of the mammary gland to produce abundant hemophilia B therapy in milk, Jianguo Zhao, Weijie Xu, Jason W. Ross, Eric M. Walters, Stephen P. Butler, Jeff J. Whyte, Lindsey Kelso, Mostafa Fatemi, Nicholas C. Vanderslice, Keith Giroux, Lee D. Spate, Melissa S. Samuel, Cliff N. Murphy, Kevin D. Wells, Nick C. Masiello, Randall S. Prather, and William H. Velander
2014
Convection enhanced delivery and in vivo imaging of polymeric nanoparticles for the treatment of malignant glioma, Giovanna M. Bernal, Michael J. LaRiviere, Nassir Mansour, Peter Pytel, Kirk E. Cahill, David J. Voce, Shijun Kang, Rubin Spretz, Ulrich Welp, Sandra E. Noriega, Luis Nunez, Gustavo F. Larsen, Ralph R. Weichselbaum, and Bakhtiar Yamini
Information in Biological Systems and the Fluctuation Theorem, Yaşar Demirel
Student Self-Assessment of ACE 10 Outcomes, Yaşar Demirel
Developing Defined and Scalable 3D Culture Systems for Culturing Human Pluripotent Stem Cells at High Densities, Yuguo Lei, Daeun Jeong, Jifang Xiao, and David V. Schaffer
Assessing the Metabolic Impact of Nitrogen Availability Using a Compartmentalized Maize Leaf Genome-Scale Model, Margaret Simmons, Rajib Saha, Nardjis Amiour, Akhil Kumar, Lenaïg Guillard, Gilles Clément, Martine Miquel, Zhenni Li, Gregory Mouille, Peter J. Lea, Bertrand Hirel, and Costas D. Maranas
Tactile Imaging of an Imbedded Palpable Structure for Breast Cancer Screening, Chieu Van Nguyen and Ravi Saraf
Tactile Imaging of an Imbedded Palpable Structure for Breast Cancer Screening, Chieu Van Nguyen and Ravi F. Saraf
Development of a Fatal Noncompressible Truncal Hemorrhage Model with Combined Hepatic and Portal Venous Injury in Normothermic Normovolemic Swine, Ujwal R. Yanala, Jason M. Johanning, Iraklis I. Pipinos, Gustavo F. Larsen, William H. Velander, and Mark A. Carlson
Development of a Fatal Noncompressible Truncal Hemorrhage Model with Combined Hepatic and Portal Venous Injury in Normothermic Normovolemic Swine, Ujwal R. Yanala, Jason M. Johanning, Iraklis I. Pipinos, Gustavo F. Larsen, William H. Velander, and Mark A. Carlson
2013
Synthetic biology of cyanobacteria: unique challenges and opportunities, Bertram M. Berla, Rajib Saha, Cheryl M. Immethun, Costas D. Maranas, Tae Seok Moon, and Himadri B. Pakras
Sustainable Operations for Distillation Columns, Yaşar Demirel
In vitro evaluation of PEGylated mesoporous MgFe2O4 magnetic nanoassemblies (MMNs) for chemo-thermal therapy, Sunil Kumar, Amita Daverey, Niroj Kumar Sahu, and Dhirendra Bahadur
A fully defined and scalable 3D culture system for human pluripotent stem cell expansion and differentiation, Yuguo Lei and David V. Schaffer
Mechanotransduction of Ultrasound is Frequency Dependent Below the Cavitation Threshold, Tobias M. Louw, Gaurav Budhiraja, Hendrik J. Viljoen, and Anuradha Subramanian
New Potential Therapeutic Approach for the Treatment of B-Cell Malignancies Using Chlorambucil/ Hydroxychloroquine-Loaded Anti-CD20 Nanoparticles, Nelly Mezzaroba, Sonia Zorzet, Erika Secco, Stefania Biffi, Claudio Tripodo, Marco Calvaruso, Ramiro Mendoza-Maldonado, Sara Capolla, Marilena Granzotto, Ruben Spretz, Gustavo F. Larsen, Sandra Noriega, Marianna Lucafó, Eduardo Mansilla, Chiara Garrovo, Gustavo H. Marín, Gabriele Bai, Valter Gattei, Gabriele Pozzato, Luis Núñez, and Paolo Macor
The Effect of Ultrasound Stimulation on the Cytoskeletal Organization of Chondrocytes Seeded In 3D Matrices, Sandra Noriega, Gulnara Hasanova, and Anuradha Subramanian
Ultrasonic Bioreactor as a Platform for Studying Cellular Response, Anuradha Subramanian, Joseph A. Turner, Gaurav Budhiraja, Sanjukta Guha Thakurta, Nicholas P. Whitney, and Sai Siddhartha Nudurupati
2012
Forced wave motion with internal and boundary damping, Tobias Louw, Scott Whitney, Anu Subramanian, and Hendrik J. Viljoen
Ultra-soft 100 nm Thick Zero Poisson’s Ratio Film with 60% Reversible Compressibility, Chieu Nguyen, Vivek Maheshwari, and Ravi Saraf
Remodeling of chromatin under low intensity diffuse ultrasound, Sandra Noriega, Gaurav Budhiraja, and Anuradha Subramanian
Effect of Fiber Diameter on the Spreading, Proliferation and Differentiation of Chondrocytes on Electrospun Chitosan Matrices, Sandra E. Noriega, Gulnara I. Hasanova, Min Jeong Schneider, Gustavo F. Larsen, and Anuradha Subramanian
Generalized ellipsometry in-situ quantification of organic adsorbate attachment within slanted columnar thin films, Keith B. Rodenhausen Jr., Daniel Schmidt, Tadas Kasputis, Angela K. Pannier, Eva Schubert, and Mathias Schubert
Reconstruction and Comparison of the Metabolic Potential of Cyanobacteria Cyanothece sp. ATCC 51142 and Synechocystis sp. PCC 6803, Rajib Saha, Alex T. Verseput, Bertram M. Berla, Thomas J. Mueller, Himadri B. Pakrasi, and Costas D. Maranas
Design and Characterization of Micro-Porous Hyaluronic Acid Hydrogels for in vitro Gene Transfer to mMSCs, Talar Tokatlian, Cynthia Cam, Shayne N. Siegman, Yuguo Lei, and Tatiana Segura
Integrin-mediated mechanotransduction pathway of low-intensity continuous ultrasound in human chondrocytes, Nicholas P. Whitney, Allyson C. Lamb, Tobias M. Louw, and Anuradha Subramanian
2011
INDUCTION OF TOLERANCE BY ORAL ADMINISTRATION OF FACTOR VIII AND TREATMENT OF HEMOPHILA, Oral Alpan, Tirumalai Kamala, Polly Matzinger, and William Hugold Velander
PRODUCTION OF HIGH LEVELS OF TRANSGENC FACTOR IX WITHOUT GENE RESCUE, AND ITS THERAPEUTIC USES, Julian D. Cooper, William Hugold Velander, and Tanya K. O'Sickey
POLY(PHENYLENE)-BASEDANION EXCHANGEMEMBRANE, Michael Hibbs, Christopher J. Cornelius, and Cy H. Fujimoto
The spreading, migration and proliferation of mouse mesenchymal stem cells cultured inside hyaluronic acid hydrogels, Yuguo Lei, Shiva Gojgini, Jonathan Lam, and Tatiana Segura
Hyaluronic Acid and Fibrin Hydrogels with Concentrated DNA/ PEI Polyplexes for Local Gene Delivery, Yuguo Lei, Maha Rahim, Quinn Ng, and Tatiana Segura
Experimental Validation of a Fundamental Model for PCR Efficiency, Tobias M. Louw, Christine S. Booth, Elsje Pienaar, Joel R. TerMaat, Scott E. Whitney, and Hendrik J. Viljoen
Could Metabolic Syndrome, Lipodystrophy, and Aging Be Mesenchymal Stem Cell Exhaustion Syndromes?, Eduardo Mansilla, Vanina Díaz Aquino, Daniel Zambón, Gustavo Horacio Marin, Karina Mártire, Gustavo Roque, Thomas Ichim, Neil H. Riordan, Amit Patel, Flavio Sturla, Gustavo F. Larsen, Rubén Spretz, Luis Núñez, Carlos Soratti, Ricardo Ibar, Michiel van Leeuwen, José María Tau, Hugo Drago, and Alberto Maceira
Process Development and cGMP Manufacturing of a Recombinant Ricin Vaccine: an Effective and Stable Recombinant Ricin A-Chain Vaccine—RVEcTM, Michael M. Meagher, Javier G. Seravalli, S. Todd Swanson, Roger G. Ladd, Yogender P. Khasa, Mehmet Inan, Jay C. Harner, Scott K. Johnson, Kevin E. Van Cott, Changhong Lindsey, Robert Wannemacher, and Leonard A. Smith
Using Thermally Coupled Reactive Distillation Columns in Biodiesel Production, Nghi Nguyen and Yaşar Demirel
A Novel Biodiesel and Glycerol Carbonate Production Plant, Nghi T. Nguyen and Yaşar Demirel
Impact of Porogens on the Pore Characteristics of Zirconia Particles Made by Polymer-Induced Colloid Aggregation, Abhinandan Pattanayak and Anuradha Subramanian
Functional factor VIII made with von Willebrand factor at high levels in transgenic milk, Steven W. Pipe, Hongzhi Miao, Stephen P. Butler, Jennifer Calcaterra, and William H. Velander
Combined optical and acoustical method for determination of thickness and porosity of transparent organic layers below the ultra-thin film limit, Keith B. Rodenhausen Jr., Tadas Kasputis, Angela K. Pannier, J. Y. Gerasimov, R. Y. Lai, M. Solinsky, T. E. Tiwald, H. Wang, Amitabha Sarkar, Tino Hofmann, Natale J. Ianno, Mathias Schubert, and Jennifer Y. Gerasimov
Zea mays iRS1563: A Comprehensive Genome-Scale Metabolic Reconstruction of Maize Metabolism, Rajib Saha, Patrick F. Suthers, and Costas D. Maranas
Improved cellular infiltration into nanofibrous electrospun crosslinked gelatin scaffolds templated with micrometer sized polyethylene glycol fibers, Maciej Skotak, Jorge Ragusa, Daniela Gonzalez, and Anuradha Subramanian
HYBRID MEMBRANE-PSA SYSTEM FOR SEPARATING OXYGEN FROMAR, Chad L. Staiger, Mark R. Vaughn, A. Keith Miller, and Christopher J. Cornelius
2010
Efficiency of the Polymerase Chain Reaction, Christine S. Booth, Elsje Pienaar, Joel R. Termaat, Scott E. Whitney, Tobias M. Louw, and Hendrik J. Vijoen
Nonequilibrium Thermodynamics Modeling of Coupled Biochemical Cycles in Living Cells, Yaşar Demirel
High throughput quantification of N-glycans using one-pot sialic acid modification and matrix assisted laser desorption ionization time of flight mass spectrometry, Geun-Cheol Gil, Bryce Iliff, Ron Cerny, William H. Velander, and Kevin E. Van Cott
, Geun-Cheol Gil, William H. Velander, and Kevin E. Van Cott
Fed-batch fermentation of GM-CSF-producing glycoengineered Pichia pastoris under controlled specific growth rate, Pieter P. Jacobs, Mehmet Inan, Nele Festjens, Jurgen Haustraete, Annelies Van Hecke, Roland Contreras, Michael M. Meagher, and Nico Callewaert
Propofol induces MAPK/ERK cascade dependant expression of cFos and Egr-1 in rat hippocampal slices, Srivatsan Kidambi, Joel Yarmush, Yevgeny Berdichevsky, Sangeetha Kamath, Wayne Fong, and Joseph SchianodiCola
Optimization and Economic Evaluation of Industrial Gas Production and Combined Heat and Power Generation from Gasification of Corn Stover and Distillers Grains, Ajay Kumar, Yaşar Demirel, David D. Jones, and Milford Hanna
Incorporation of Active DNA/Cationic Polymer Polyplexes into Hydrogel Scaffolds, Yuguo Lei, Suxian Huang, Pooria Sharif-Kashani, Yong Chen, Pirouz Kavehpour, and Tatiana Segura
Two and Three-dimensional Gene Transfer from Enzymatically Degradable Hydrogel Scaffolds, Yuguo Lei, Quinn K.T. Ng, and Tatiana Segura
Retrofit of Distillation Columns in Biodiesel Production Plants, Nghi Nguyen and Yaşar Demirel
A Model of Tuberculosis Transmission and Intervention Strategies in an Urban Residential Area, Elsje Pienaar, Aaron M. Fluitt, Scott E. Whitney, Alison G. Freifeld, and Hendrik J. Viljoen
FABRICATION OF ULTRA LONG NECKLACE OF NANOPARTICLES, Ravi Saraf, Sanjun Niu, Vikas Berry, and Vivek Maheshwari
2009
Thermodynamically Coupled Heat and Mass Flows in a Reaction-Transport System with External Resistances, Yaşar Demirel
Propofol induces ERK-dependant expression of c-Fos and Egr-1 in neuronal cells, Srivatsan Kidambi, Joel Yarmush, Wayne Fong, Sangeetha Kamath, Joseph SchianodiCola, and Yaakov Nahmias
Oxygen-mediated enhancement of primary hepatocyte metabolism, functional polarization, gene expression, and drug clearance, Srivatsan Kidambi, Rubin S. Yarmush, Eric Novik, Piyun CHao, Martin L. Yarmush, and Yaakov Nahmias
Simulation of Corn Stover and Distillers Grains Gasification with Aspen Plus, Ajay Kumar, Hossein Noureddini, Yaşar Demirel, David Jones, and Milford Hanna
DNA Delivery from Matrix Metalloproteinase Degradable Poly (ethylene glycol) Hydrogels to Mouse Cloned Mesenchymal Stem Cells, Yuguo Lei and Tatiana Segura
Gene synthesis by integrated polymerase chain assembly and PCR amplification using a high-speed thermocycler, Joel R. TerMaat, Elsje Pienaar, Scott E. Whitney, Tarlan G. Mamedov, and Anuradha Subramanian
A kinetic study of in vitro lysis of Mycobacterium smegmatis , William J. Valente, Elsje Pienaar, A. Fast, A. Fluitt, Scott E. Whitney, Robert J. Fenton, Raul G. Barletta, O. Chacon, and Hendrik J. Viljoen
2008
Modeling of Thermodynamically Coupled Reaction-Transport Systems, Yaşar Demirel
Thermodynamically Coupled Transport in Simple Catalytic Reactions, Yaşar Demirel
Analysis of the N-glycans of recombinant human Factor IX purified from transgenic pig milk, Geun-Cheol Gil, William H. Velander, and Kevin E. Van Cott
Removal of Phenols with Encapsulated Horseradish Peroxidase in Calcium Alginate, Alemzadeh Iran and Siamak Nejati
Tunable Resistive m-dPEG Acid Patterns on Polyelectrolyte Multilayers at Physiological Conditions: Template for Directed Deposition of Biomacromolecules, Srivatsan Kidambi, Christina Chan, and Ilsoon Lee
Primary Neuron/Astrocyte Co-Culture on Polyelectrolyte Multilayer Films: A Template for Studying Astrocyte-Mediated Oxidative Stress in Neurons, Srivatsan Kidambi, Ilsoon Lee, and Christina Chan
Polyelectrolyte mediated scalable synthesis of highly stable silver nanocubes in less than a minute using microwave irradiation, Subrata Kundu, Vivek C. Maheshwari, Sanjun Niu, and Ravi F. Saraf
Web-based applications for building, managing and analysing kinetic models of biological systems, Dong-Yup Lee, Rajib Saha, Faraaz Noor Khan Yusufi, Wonjun Park, and IftekharA. Karimi
Cell Adhesion On Surfaces Of Varying Topographies, Ilsoon Lee, Christina Chan, and Srivatsan Kidambi
Self-Assembly of a Micrometers-Long One-Dimensional Network of Cemented Au Nanoparticles, Vivek C. Maheshwari, Jennifer Kane, and Ravi F. Saraf
A Fundamental Study of the PCR Amplification of GC-rich DNA Templates, T. G. Mamedov, Elsje Pienaar, Scott E. Whitney, Joel R. TerMaat, G. Carvill, R. Goliath, Anuradha Subramanian, and Hendrik J. Viljoen
Control On Platelet Adhesion And Activation Events By Selective And Specific Binding Of Plasma Protein On Peptide-Coupled Surface, Anuradha Subramanian and Sanjukta Guha-Thankruta
Importance of Annealing Times in the PCR Amplification of GC-Rich Genes, Anuradha Subramanian, Tarlan Mamedov, Elsje Pinnear, and Hendrik J. Viljoen
Characterization of a Polymer Surface With Sequentially Immobilized Proteins, Anuradha Subramanian, Tarlan Mammedov, and Karl E. Kador
Effect Of Intermittent Applications Of Continuous Ultrasound Signal On The Morphology And Cytoskeletal Organization In Chondrocytes, Anuradha Subramanian, Sandra Noriega, and Gulnara Hasanova
TRANSGENIC NONHUMAN MAMMALS PRODUCING FIBRINOGEN IN MILKAND METHODS OF PRODUCING FIBRIN, William H. Velander, William N. Drohan, Henryk Lubon, and John L. Johnson