Kenneth Nickerson, Professor
School of Biological Sciences

Dr. Nickerson is a Microbial Physiologist and Biochemist with broad interests in bacterial, fungal, and algal systems. Active areas of research include: fungal dimorphism in Candida albicans and Ceratocystis ulmi; farnesol as a quorum sensing molecule (QSM) produced by C. albicans; farnesol’s mode of action as a QSM and as a virulence factor; anaerobic growth of C. albicans; urea metabolism in C. albicans and other fungi; biotinylated histones in C. albicans; chlamydospore formation in C. albicans; high cell density QSMs from diatoms and other algae; microbial ecology of alkaline lakes in Western Nebraska. Past research areas included: Bacillus thuringiensis and other microbial insecticides, mechanisms of bacterial detergent resistance, and the physiological functions of polyamines in microbes. His lab and office are in the Beadle Center,

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2016

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Killer toxin from several food-derived Debaryomyces hansenii strains effective against pathogenic Candida yeasts, Nabaraj Banjara, Kenneth Nickerson, Mallory J. Suhr, and Heather E. Hallen-Adams

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Comparative genomics, transcriptomics, and physiology distinguish symbiotic from free-living Chlorella strains, Cristian F. Quispe, Olivia Sonderman, Maya Khasin, Wayne R. Riekhof, James L. Van Etten, and Kenneth Nickerson

2015

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Proteomic Adaptations to Starvation Prepare Escherichia coli for Disinfection Tolerance, Zhe Du, Renu Nandakumar, Kenneth W. Nickerson, and Xu Li

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Candida albicans Quorum Sensing Molecules Stimulate Mouse Macrophage Migration, Jessica C. Hargarten, Tyler C. Moore, Thomas M. Petro, Kenneth W. Nickerson, and Audrey L. Atkin

2014

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A Glutathione-independent Glyoxalase of the DJ-1 Superfamily Plays an Important Role in Managing Metabolically Generated Methylglyoxal in Candida albicans, Sahar Hasim, Nur Ahmad Hussin, Fadhel Alomar, Keshore R. Bidasee, Kenneth W. Nickerson, and Mark A. Wilson

2013

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Histone biotinylation in Candida albicans, Sahar Hasim, Swetha Tati, Nandakumar Madayiputhiya, Renu Nandakumar, and Kenneth W. Nickerson

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Candida albicans Czf1 and Efg1 Coordinate the Response to Farnesol during Quorum Sensing, White-Opaque Thermal Dimorphism, and Cell Death, Melanie L. Langford, Jessica C. Hargarten, Krista D. Patefield, Elizabeth Marta, Jill R. Blankenship, Saranna Fanning, Kenneth W. Nickerson, and Audrey L. Atkin

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Candida albicans Czf1 and Efg1 Coordinate the Response to Farnesol during Quorum Sensing, White-Opaque Thermal Dimorphism, and Cell Death, Melanie L. Langford, Jessica C. Hargarten, Krista D. Patefield, Elizabeth Marta, Jill R. Blankenship, Saranna Fanning, Kenneth W. Nickerson, and Audrey L. Atkin

2012

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Quorum sensing activity in Ophiostoma ulmi: effects of fusel oils and branched chain amino acids on yeast-mycelial dimorphism, A. Berrocal, J. Navarrete, C. Oviedo, and K. W. Nickerson

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Urea Amidolyase (DUR1,2) Contributes to Virulence and Kidney Pathogenesis of Candida albicans, Dhammika H. M. L. P Navarathna, Michail S. Lionakis, Martin J. Lizak, Jeeva Munasinghe, Kenneth W. Nickerson, and David D. Roberts

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Quorum Sensing and Other Aspects of the Biology of Candida albicans, Kenneth W. Nickerson

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Reducing odorous VOC emissions from swine manure using soybean peroxidase and peroxides, David B. Parker, Lingshuang Cai, Ki-Hyun Kim, Kristin E. Hales, Mindy J. Spiehs, Bryan L. Woodbury, Audrey L. Atkin, Kenneth Nickerson, and Krista D. Patefield

2011

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Zap1 Control of Cell-Cell Signaling in Candida albicans Biofilms, Shantanu Ganguly, Andrew C. Bishop, Wenjie Xu, Suman Ghosh, Kenneth W. Nickerson, Frederick Lanni, Jana Patton-Vogt, and Aaron P. Mitchell

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Dur3 is the major urea transporter in Candida albicans and is co-regulated with the urea amidolyase Dur1,2, Dhammika H. M. L. P Navarathna, Aditi Das, Joachim Morschhauser, Kenneth W. Nickerson, and David D. Roberts

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Molecular evolution of urea amidolyase and urea carboxylase in fungi, Pooja K. Strope, Kenneth W. Nickerson, Steven D. Harris, and Etsuko Moriyama

2010

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Candida albicans cellwall components and farnesol stimulate the expression of both inflammatory and regulatory cytokines in the murine RAW264.7 macrophage cell line, Suman Ghosh, Nina Howe, Katie Volk, Swetha Tati, Kenneth W. Nickerson, and Thomas M. Petro

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Activity and Toxicity of Farnesol towards Candida albicans Are Dependent on Growth Conditions, Melanie L. Langford, Sahar Hasim, Kenneth W. Nickerson, and Audrey L. Atkin

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Evolutionary aspects of urea utilization by fungi, Dhammika H. M. L. P Navarathna, Steven D. Harris, David D. Roberts, and Kenneth W. Nickerson

2009

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Arginine-Induced Germ Tube Formation in Candida albicans Is Essential for Escape from Murine Macrophage Line RAW 264.7, Suman Ghosh, Dhammika H. M. L. P. Navarathna, David D. Roberts, Jake T. Cooper, Audrey L. Atkin, Thomas M. Petro, and Kenneth Nickerson

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Escherichia coli O157:H7 and Other E. coli Strains Share Physiological Properties Associated with Intestinal Colonization, Lisa Jacobsen, Lisa Durso, Tyrell Conway, and Kenneth W. Nickerson

2008

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Regulation of Aromatic Alcohol Production in Candida albicans, Suman Ghosh, Bessie W. Kebaara, Audrey L. Atkin, and Kenneth W. Nickerson

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Candida albicans Tup1 Is Involved in Farnesol-Mediated Inhibition of Filamentous-Growth Induction, Bessie W. Kebaara, Melanie L. Langford, Dhammika H. M. L. P. Navarathna, Raluca Dumitru, Kenneth W. Nickerson, and Audrey L. Atkin

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Influence of heterocyclic and oxime-containing farnesol analogs on quorum sensing and pathogenicity in Candida albicans, Roman Shchepin, Dhammika H.M.L.P. Navarathna, Raluca Dumitru, Shane Lippold, Kenneth Nickerson, and Patrick Dussault

2007

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In Vivo and In Vitro Anaerobic Mating in Candida albicans, Raluca Dumitru, Dhammika H.M.L.P. Navarathna, Camile P. Semighini, Christian G. Elowsky, Razvan Dumitru, Daniel Dignard, Malcom Whiteway, Audrey L. Atkin, and Kenneth Nickerson

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Effect of Farnesol on a Mouse Model of Systemic Candidiasis, Determined by Use of a DPP3 Knockout Mutant of Candida albicans, Dhammika H.M.L.P. Navarathna, Jacob M. Hornby, Navasona Krishnan, Anne M. Parkhurst, Gerald E. Duhamel, and Kenneth Nickerson

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Exogenous Farnesol Interferes with the Normal Progression of Cytokine Expression during Candidiasis in a Mouse Model, Dhammika H. M. L. P. Navarathna, Kenneth Nickerson, Gerald E. Duhamel, Thomas R. Jerrels, and Thomas M. Petro

2006

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Quorum Sensing in Dimorphic Fungi: Farnesol and Beyond, Kenneth Nickerson, Audrey L. Atkin, and Jacob M. Hornby

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Pichia pastoris fermentation optimization: energy state and testing a growth-associated model , Bradley A. Plantz, Jayanta Sinha, Lorelie Villarete, Kenneth Nickerson, and Vicki Schlegel

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Farnesol-induced apoptosis in Aspergillus nidulans reveals a possible mechanism for antagonistic interactions between fungi, Camile P. Semighini, Jacob M. Hornby, Raluca Dumitru, Kenneth Nickerson, and Steven D. Harris

2005

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Surface Display of Recombinant Proteins on Bacillus thuringiensis Spores, Cheng Du, Wing C. Chan, Timothy W. McKeithan, and Kenneth Nickerson

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Farnesol Concentrations Required To Block Germ Tube Formation in Candida albicans in the Presence and Absence of Serum, Daniel D. Mosel, Raluca Dumitru, Jacob M. Hornby, Audrey L. Atkin, and Kenneth Nickerson

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Enhanced pathogenicity of Candida albicans pre-treated with subinhibitory concentrations of fluconazole in a mouse model of disseminated candidiasis, Dhammika H.M.L.P. Navarathna, Jacob M. Hornby, Natasha Hoerrmann, Anne M. Parkhurst, Gerald E. Duhamel, and Kenneth Nickerson

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Survey of Extreme Solvent Tolerance in Gram-Positive Cocci: Membrane Fatty Acid Changes in Staphylococcus haemolyticus Grown in Toluene, Lindsey E. Nielsen, Dana R. Kadavy, Soumitra Rajagopal, Rhae A. Drijber, and Kenneth Nickerson

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Biologically Active Fluorescent Farnesol Analogs, Roman Shchepin, Razvan Dumitru, Kenneth Nickerson, Miranda Lund, and Patrick Dussault

2004

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Defined Anaerobic Growth Medium for Studying Candida albicans Basic Biology and Resistance to Eight Antifungal Drugs, Raluca Dumitru, Jacob M. Hornby, and Kenneth Nickerson

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Inoculum Size Effect in Dimorphic Fungi: Extracellular Control of Yeast-Mycelium Dimorphism in Ceratocystis ulmi, Jacob M. Hornby, Sarah M. Jacobitz-Kizzier, Donna J. McNeel, Ellen C. Jensen, David S. Treves, and Kenneth Nickerson

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Enhanced Production of Farnesol by Candida albicans Treated with Four Azoles, Jacob M. Hornby and Kenneth Nickerson

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Activity of gut proteinases from Cry1Ab-selected colonies of the European corn borer, Ostrinia nubilalis (Lepidoptera: Crambidae), Herbert A. A. Siqueira, Kenneth Nickerson, Daniel Moellenbeck, and Blair D. Siegfried

2003

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Farnesol Biosynthesis in Candida albicans: Cellular Response to Sterol Inhibition by Zaragozic Acid B, Jacob M. Hornby, Bessie W. Kebaara, and Kenneth Nickerson

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Phenotype of the Triplo-lethal locus of Drosophila melanogaster and its suppression by hyperoxia, Laura K. Smoyer, Douglas R. Dorer, Kenneth Nickerson, and Alan C. Christensen

2002

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Ornithine Decarboxylase Encoded by Chlorella Virus PBCV-1, Tiara A. Morehead,; James R. Gurnon; Byron Adams; Kenneth Nickerson; Lisa A. Fitzgerald; and James L. Van Etten

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Sodium Dodecyl Sulfate Hypersensitivity of clpP and clpB Mutants of Escherichia coli, Soumitra Rajagopal, Narasimhan Sudarsan, and Kenneth Nickerson

2001

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Quorum Sensing in the Dimorphic Fungus Candida albicans Is Mediated by Farnesol, Jacob M. Hornby, Ellen C. Jensen, Amber C. Lisec, Joseph J. Tasto, Brandon Jahnke, Richard Shoemaker, Patrick Dussault, and Kenneth Nickerson

2000

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Natural Antibiotic Resistance of Bacteria Isolated from Larvae of the Oil Fly, Helaeomyia petrolei, Dana R. Kadavy, Jacob M. Hornby, Terry Haverkost, and Kenneth Nickerson

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Influence of Infected Cell Growth State on Bacteriophage Reactivation Levels, Dana R. Kadavy, Julie J. Shaffer, Susan E. Lott, Thomas A. Wolf, Cathy E. Bolton, William H. Gallimore, Eugene L. Martin, Kenneth Nickerson, and Tyler A. Kokjohn

1999

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Microbiology of the Oil Fly, Helaeomyia petrolei, Dana R. Kadavy, Bradley A. Plantz, Christopher A. Shaw, Jill Myatt, Tyler A. Kokjohn, and Kenneth Nickerson

1998

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Metathesis-based synthesis of jasmonate and homojasmonate lactones, candidates for extracellular quorum sensing molecules in Candida albicans, Su C. Cho, Patrick Dussault, Amber D. Lisec, Ellen C. Jensen, and Kenneth W. Nickerson

1996

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Bacillus thuringiensis HD-73 Spores Have Surface-Localized Cry1Ac Toxin: Physiological and Pathogenic Consequences, Cheng Du and Kenneth Nickerson

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The Bacillus thuringiensis Insecticidal Toxin Binds Biotin-Containing Proteins, Cheng Du and Kenneth Nickerson

1994

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Comparison of Disulfide Contents and Solubility at Alkaline pH of Insecticidal and Noninsecticidal Bacillus thuringiensis Protein Crystals, Cheng Du, Phyllis A.W. Martin, and Kenneth Nickerson

1993

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Nonenzymatic Glycosylation of Lepidopteran-Active Bacillus thuringiensis Protein Crystals, Meenakshi Bhattacharyi, Bradley A. Plantz, Jane D. Swanson-Kobler, and Kenneth Nickerson

1992

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The Entner-Doudoroff Pathway in Escherichia coli Is Induced for Oxidative Glucose Metabolism via Pyrroloquinoline Quinone-Dependent Glucose Dehydrogenase, Ronda Fliege, Suxiang Tong, Annemarie Shibata, Kenneth Nickerson, and Tyrrell Conway

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Lipoxygenase Inhibitors Shift the Yeast/Mycelium Dimorphism in Ceratocystis ulmi, Ellen C. Jensen, Clyde Ogg, and Kenneth Nickerson

1991

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Nutritional Complementation of Oxidative Glucose Metabolism in Escherichia coli via Pyrroloquinoline Quinone-Dependent Glucose Dehydrogenase and the Entner-Doudoroff Pathway, Michael Adamowicz, Tyrrell Conway, and Kenneth Nickerson

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Detergent (Sodium Dodecyl Sulfate) Shock Proteins in Escherichia coli, Michael Adamowicz, Philip M. Kelley, and Kenneth Nickerson

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Insect immune response to bacterial infection is mediated by eicosanoids, David W. Stanley-Samuelson, Ellen Jensen, Kenneth Nickerson, Kristina C. Tiebel, Clyde Ogg, and Ralph W. Howard

1990

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Toxicity of Protease-Resistant Domains from the Delta-Endotoxin of Bacillus thuringiensis subsp. israelensis in Culex quinquefasciatus and Aedes aegypti Bioassays, Mary Ann Pfannenstiel, William C. Cray Jr., Graham Couche, and Kenneth Nickerson

1988

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Prevalence of Broad-Host-Range Lytic Bacteriophages of Sphaerotilus natans, Escherichia coli, and Pseudomonas aeruginosa, Ellen C. Jensen, Holly S. Schrader, Brenda Rieland, Thomas L. Thompson, Kit W. Lee, Kenneth Nickerson, and Tyler A. Kokjohn

1987

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Structural Disulfide Bonds in the Bacillus thuringiensis subsp. israelensis Protein Crystal, Graham A. Couche, Mary A. Pfannenstiel, and Kenneth Nickerson

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The Glycoprotein Toxin of Bacillus thuringiensis subsp. israelensis Indicates a Lectinlike Receptor in the Larval Mosquito Gut, Ganapathy Muthukumar and Kenneth Nickerson

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Amino Sugars in the Glycoprotein Toxin from Bacillus thuringiensis subsp. israelensis, Mary Ann Pfannenstiel, Ganapathy Muthukumar, Graham A. Couche, and Kenneth Nickerson

1986

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Immunological Relationships among Proteins Making Up the Bacillus thuringiensis subsp. israelensis Crystalline Toxin, Mary Ann Pfannenstiel, Graham A. Couche, Elise J. Ross, and Kenneth Nickerson